The No. 17 USC Trojans (7-2) square off against a conference opponent when they host the Iowa Hawkeyes (6-3) on Saturday, November 15, 2025 at Los Angeles Memorial Coliseum in a Big Ten showdown.

The Hawkeyes are underdogs, but by less than a touchdown (+6.5), versus the Trojans (with an over/under of 48.5 points).

Below you’ll find our betting primer for this this contest between the Trojans and the Hawkeyes, and uncover all of our betting picks here, too!

USC vs. Iowa betting lines

• Spread favorite: Trojans (-6.5)
• Moneyline: Trojans (-241), Hawkeyes (+196)
• Total: 48.5 points
• TV Channel: Big Ten Network
• Live Stream: Fubo

USC vs. Iowa betting info and stats

USC has an against-the-spread record of 5-4-0 this season. USC has covered the spread three times when the favorite by at least 6.5 points (a 3-3 ATS record). USC has put up a 7-1 record in the eight games this season it has been favored on the moneyline. Iowa has a 6-2-1 record against the spread this season. When Iowa is an underdog by 6.5 points or more, it is 1-0 ATS. This will be the fourth time this year Iowa is the moneyline underdog, and have lost every such contest.

USC vs. Iowa recent stats and trends

USC Trojans

• USC is 2-1 against the spread and 2-1 overall in its past three contests.
• USC and its opponents have combined to hit the over in one of those games.
• USC’s last three outings have ended with an average of 57.8 points scored. That’s 9.3 more points than this contest’s over/under.

Iowa Hawkeyes

• Iowa is 2-1 against the spread and 2-1 overall in its last three games.
• In two of those three games, the final combined score has gone over the set total.
• The last three Iowa games averaged 40.8 total points, 7.7 fewer points than this matchup’s point total.

USC vs. Iowa key players

USC Trojans

• Jayden Maiava has thrown for 2,614 yards (290.4 ypg) to lead USC, completing 66.2% of his passes and recording 17 touchdown passes compared to six interceptions this season. He’s also figured in the ground game with 113 rushing yards on 38 carries with six rushing touchdowns.
• King Miller has racked up 636 yards on 80 carries while finding paydirt five times.
• Waymond Jordan has collected 576 yards on 88 carries, scoring five times.
• Makai Lemon’s leads his squad with 937 yards as a receiver. He’s racked up that yardage on 61 receptions (out of 77 targets) and scored seven touchdowns.
• Ja’Kobi Lane has hauled in 33 passes while averaging 65.0 yards per game and scoring four touchdowns.
• Lake McRee has a total of 370 receiving yards so far this year, grabbing 21 passes and scoring two touchdowns.
• Kameryn Fountain has racked up 3.5 sacks to lead the team, while also recording 5.0 TFL and 14 tackles.
• Eric Gentry is the team’s top-tackler this year. He’s amassed 39 tackles, 4.0 TFL, and three sacks.
• Bishop Fitzgerald leads the team with five interceptions, while also putting up 29 tackles, 2.0 TFL, one sack, and five passes defended.

Iowa Hawkeyes

• Mark Gronowski has thrown for 1,084 yards on 117-of-183 passing with five touchdowns and four interceptions this season. He has chipped on the ground, as well, with 338 yards and 12 rushing touchdowns.
• Kamari Moulton has rushed for 522 yards on 105 carries so far this year while scoring two times on the ground. He’s also tacked on 12 catches, totaling 80 yards.
• Sam Phillips has collected 13 receptions this season and his team-high yardage total sits at 216 (24.0 yards per game). He’s been targeted 22 times.
• Jacob Gill has put together a 193-yard season so far. He’s caught 17 passes on 30 targets.
• Kaden Wetjen’s 17 receptions (on 19 targets) have netted him 132 yards (16.5 ypg) and one touchdown.
• Max Llewellyn has racked up 6.0 sacks to lead the team, while also picking up 7.0 TFL and 20 tackles.
• Iowa’s leading tackler, Karson Sharar, has 55 tackles, 4.0 TFL, and one sack this year.
• DeShaun Lee has a team-high two interceptions to go along with 26 tackles, 1.0 TFL, and two passes defended.