The Duke Blue Devils (5-4) take on a fellow ACC foe when they host the No. 20 Virginia Cavaliers (8-2) on Saturday, November 15, 2025 at Brooks Field at Wallace Wade Stadium.

The Cavaliers are underdogs, but by less than a touchdown (+4.5), versus the Blue Devils (with an over/under of 59.5 points).

Read on for our betting preview for this this game between the Blue Devils and the Cavaliers, and find all of our predictions here, too!

Duke vs. Virginia betting lines

• Spread favorite: Blue Devils (-4.5)
• Moneyline: Blue Devils (-192), Cavaliers (+159)
• Total: 59.5 points
• TV Channel: ESPN2
• Live Stream: Fubo

Duke vs. Virginia betting info and stats

Duke has four wins against the spread in nine opportunities so far this season (4-5-0). Duke is winless ATS (0-2) when favorites by at least 4.5 points. In the six games favored on the moneyline, Duke has recorded a 4-2 record. Virginia has six wins against the spread so far this season (6-4-0). In the two games Virginia has been an underdog by at least 4.5 points this season, it has covered the spread both times. Virginia has a 2-1 record this year in games it hs played as an underdog on the moneyline.

Duke vs. Virginia recent stats and trends

Duke Blue Devils

• Duke is 1-2 against the spread and 1-2 overall in its past three games.
• Duke and its opponents have combined to hit the over two times in those games.
• The past three Duke games averaged 59.5 points, equal to this matchup’s point total.

Virginia Cavaliers

• Virginia is 1-2 against the spread over its past three games, and has a 1-2 straight-up record in those matchups.
• In all three of those games, the final combined score fell short of the set total.
• Virginia’s last three outings have ended with an average of 50.8 points scored. That’s 8.7 fewer points than this contest’s over/under.

Duke vs. Virginia key players

Duke Blue Devils

• Darian Mensah has 2,794 passing yards for Duke, completing 69.8% of his passes and recording 24 touchdowns and four interceptions this season.
• The team’s top rusher, Nate Sheppard, has carried the ball 100 times for 657 yards (73.0 per game), scoring seven times. He’s also caught 21 passes for 148 yards and one touchdown.
• Anderson Castle has carried the ball 66 times for 362 yards (40.2 per game) and six touchdowns.
• Cooper Barkate has hauled in 50 catches for 824 yards (91.6 yards per game) to lead the team so far this season. He’s found the end zone five times as a receiver.
• Sean Brown has hauled in 41 receptions totaling 580 yards, finding the end zone three times as a receiver so far this campaign.
• Sahmir Hagans has racked up 30 receptions for 342 yards, an average of 38.0 yards per game. He’s scored five times as a receiver this season.
• Vincent Anthony Jr. leads the team with 6.5 sacks, and also has 9.0 TFL and 26 tackles.
• Duke’s tackle leader, Caleb Weaver, has 61 tackles, 3.0 TFL, 1.5 sacks, and one interception this year.
• Moussa Kane has picked off a team-leading two passes. He also has 14 tackles, 2.0 TFL, one sack, and two passes defended to his name.

Virginia Cavaliers

• Chandler Morris has compiled 2,088 yards on 66.7% passing while tossing 12 touchdown passes with five interceptions this season. He’s also run for 214 yards with four scores.
• J’mari Taylor has rushed 169 times for 784 yards, with 11 touchdowns. He’s also tacked on 34 catches for 160 yards.
• Harrison Waylee has taken 56 carries and totaled 314 yards with five touchdowns.
• Trell Harris leads his team with 605 receiving yards on 43 receptions with four touchdowns.
• Jahmal Edrine has caught 35 passes and compiled 431 receiving yards (43.1 per game) with one touchdown.
• Cameron Ross’ 54 targets have resulted in 35 grabs for 395 yards and two touchdowns.
• Daniel Rickert has 5.5 sacks to lead the team, and also has 5.0 TFL and 26 tackles.
• Kamren Robinson is the team’s top-tackler this year. He’s racked up 61 tackles, 2.0 TFL, two sacks, and two interceptions.
• Ja’Son Prevard has picked off a team-high three passes. He also has 19 tackles and three passes defended to his name.