The No. 13 Oklahoma Sooners (6-1) face a fellow SEC opponent when they host the No. 8 Ole Miss Rebels (6-1) on Saturday, October 25, 2025 at Gaylord Family Oklahoma Memorial Stadium.

The Rebels are underdogs, but by less than a touchdown (+4.5), against the Sooners (with an over/under of 52.5 points).

Below you’ll find our betting primer for this this game between the Sooners and the Rebels, and find all of our betting picks here, too!

Oklahoma vs. Ole Miss betting lines

• Spread favorite: Sooners (-4.5)
• Moneyline: Sooners (-198), Rebels (+164)
• Total: 52.5 points
• TV Channel: ABC (WLS – Chicago, IL)
• Live Stream: Fubo

Oklahoma vs. Ole Miss betting info and stats

Oklahoma has four wins against the spread this season (4-3-0). Oklahoma is 2-2 ATS when favored by at least 4.5 points. Oklahoma has been listed as moneyline favorites four times this season, and has recorded a 4-0 record in those matchups. Ole Miss has won four games against the spread so far this season (4-3-0). When Ole Miss is an underdog of 4.5 points or more, it has have yet to cover the spread. This is the second game this year Ole Miss is an underdog on the moneyline. The Rebels lost the first one.

Oklahoma vs. Ole Miss recent stats and trends

Oklahoma Sooners

• Oklahoma is 1-2 against the spread and 2-1 overall over its past three contests.
• The final combined score of each of the last three Oklahoma games did not go over the set point total.
• The past three Oklahoma games averaged 5.7 fewer points (46.8) than this matchup’s over/under.

Ole Miss Rebels

• Ole Miss is 1-2 against the spread and 2-1 overall during its past three matchups.
• In one of those three games, the final combined score surpassed the set total.
• The last three Ole Miss games averaged 57.5 total points, 5.0 more points than this matchup’s point total.

Oklahoma vs. Ole Miss key players

Oklahoma Sooners

• John Mateer has thrown for 1,567 yards, completing 64.9% of his passes and recording seven touchdowns and six interceptions this season. He’s also run for 209 yards (34.8 ypg) on 65 carries with five rushing touchdowns.
• Tory Blaylock has racked up 393 yards on 87 carries while finding the end zone four times.
• Isaiah Sategna’s leads his squad with 493 yards as a receiver. He’s racked up that yardage on 37 receptions (out of 57 targets) and scored four touchdowns.
• Jaren Kanak has hauled in 24 passes while averaging 52.0 yards per game.
• Deion Burks has a total of 358 receiving yards so far this year, hauling in 32 throws and scoring two touchdowns.
• R Mason Thomas has racked up 5.5 sacks to lead the team, while also recording 4.0 TFL and 18 tackles.
• Oklahoma’s top-tackler, Kip Lewis, has 19 tackles, 2.0 TFL, and 0.5 sacks this year.
• Jaydan Hardy has a team-leading one interception to go along with four tackles and one pass defended.

Ole Miss Rebels

• Trinidad Chambliss has thrown for 1,549 yards on 104-of-166 passing with eight touchdowns and one interception this season. He has chipped on the ground, as well, with 323 yards and five rushing touchdowns.
• Kewan Lacy is his team’s leading rusher with 138 carries for 618 yards, or 88.3 per game. He’s found the end zone 10 times on the ground, as well. Lacy has also chipped in with 16 catches for 97 yards.
• Harrison Wallace III’s 400 receiving yards (57.1 yards per game) lead the team. He has 21 receptions on 42 targets with two touchdowns.
• Dae’Quan Wright has 19 receptions (on 34 targets) for a total of 393 yards (56.1 yards per game) and three touchdowns this year.
• Deuce Alexander has racked up 382 reciving yards (54.6 ypg) and one touchdown this season.
• Zxavian Harris leads the team with 3.0 sacks, and also has 6.0 TFL, 29 tackles, and one interception.
• Ole Miss’ leading tackler, T.J. Dudley, has 41 tackles and 1.0 TFL this year.
• Wydett Williams Jr. has a team-leading one interception to go along with 30 tackles and one pass defended.