The No. 19 Louisville Cardinals (7-2) and the Clemson Tigers (4-5) play on Friday, November 14, 2025 at L&N Federal Credit Union Stadium in a battle of ACC opponents.

The Tigers are underdogs, but by less than a field goal (+2.5), versus the Cardinals (with an over/under of 51.5 points).

Keep reading to check out our betting preview for this this game between the Cardinals and the Tigers, and uncover all of our predictions here, too!

Louisville vs. Clemson betting lines

• Spread favorite: Cardinals (-2.5)
• Moneyline: Cardinals (-125), Tigers (+105)
• Total: 51.5 points
• TV Channel: ESPN
• Live Stream: Fubo

Louisville vs. Clemson betting info and stats

Louisville is 3-6-0 against the spread through nine opportunities this season. Louisville has covered the spread twice this season when listed as the favorite by at least 2.5 points. Louisville has been moneyline favorites for eight games this season, and it has put up a 6-2 record in those matchups. Clemson has three wins against the spread so far this season (3-6-0). Clemson has not been the underdog on the moneyline yet this season.

Louisville vs. Clemson recent stats and trends

Louisville Cardinals

• Louisville is 1-2 against the spread over its past three games, and has a 2-1 straight-up record in those matchups.
• Louisville and its opponents have hit the over in two of those games.
• The last three Louisville games averaged 52.2 total points, 0.7 more points than this matchup’s over/under.

Clemson Tigers

• Clemson is 1-2 against the spread in its past three games, and has a 2-1 straight-up record in those contests.
• Clemson and its opponents have hit the over two times in those games.
• The past three Clemson games averaged 2.3 more points (53.8) than this matchup’s point total.

Louisville vs. Clemson key players

Louisville Cardinals

• Miller Moss has thrown for 2,132 yards (236.9 ypg) to lead Louisville, completing 63.8% of his passes and tossing 11 touchdown passes compared to seven interceptions this season.
• Isaac Brown has 782 rushing yards on 91 carries with five touchdowns.
• Keyjuan Brown has been handed the ball 66 times this year and racked up 457 yards (57.1 per game) with six touchdowns.
• Chris Bell has hauled in 62 catches for 792 yards (88.0 yards per game) to lead the team so far this season. He’s found the end zone six times as a receiver.
• Caullin Lacy has caught 48 passes while averaging 53.6 yards per game and scoring two touchdowns.
• Jaleel Skinner has been the target of 22 passes and hauled in 15 grabs for 152 yards, an average of 19.0 yards per contest. He’s found the end zone one time through the air this season.
• Wesley Bailey paces the team with 5.0 sacks, and also has 4.0 TFL and 32 tackles.
• Louisville’s leading tackler, TJ Quinn, has 57 tackles, 3.0 TFL, one sack, and two interceptions this year.
• Antonio Watts has a team-leading three interceptions to go along with 30 tackles, 4.0 TFL, 2.5 sacks, and three passes defended.

Clemson Tigers

• Cade Klubnik has recored 2,136 passing yards, or 267.0 per game, so far this season. He has completed 67.9% of his passes and has thrown 14 touchdowns with five interceptions. He’s also chipped in on the ground with 14.6 rushing yards per game while scoring as a runner three times.
• The team’s top rusher, Adam Randall, has carried the ball 116 times for 570 yards (63.3 per game) with six touchdowns. He’s also caught 26 passes for 212 yards and three touchdowns.
• Gideon Davidson has run for 149 yards across 37 attempts. He’s chipped in with seven catches for 55 yards.
• Bryant Wesco Jr. has collected 31 catches this season and his team-high yardage total sits at 537 (76.7 yards per game). He’s been targeted 45 times and has six touchdowns.
• T.J. Moore has put together a 536-yard season so far with four touchdowns. He’s caught 31 passes on 53 targets.
• Antonio Williams’ 49 targets have resulted in 39 catches for 429 yards and two touchdowns.
• Will Heldt paces the team with 4.0 sacks, and also has 8.0 TFL and 29 tackles.
• Clemson’s tackle leader, Sammy Brown, has 61 tackles, 6.0 TFL, and three sacks this year.
• Ricardo Jones has picked off a team-high four passes. He also has 27 tackles, 1.0 TFL, and four passes defended to his name.