The USC Trojans (4-1) face a fellow Big Ten opponent when they host the No. 15 Michigan Wolverines (4-1) on Saturday, October 11, 2025 at Los Angeles Memorial Coliseum.

The Trojans are small favorites (-2.5) in their matchup versus the Wolverines, with the over/under at 57 points. (On the moneyline, the Trojans are -147 and the Wolverines are +123.)

Keep reading to check out our betting primer for this this matchup between the Trojans and the Wolverines, and discover all of our betting picks here, too!

USC vs. Michigan betting lines

• Spread favorite: Trojans (-2.5)
• Moneyline: Trojans (-147), Wolverines (+123)
• Total: 57 points
• TV Channel: NBC (WBGH-Binghamton, NY)
• Live Stream: Fubo

USC vs. Michigan betting info and stats

USC has won twice against the spread so far this season (2-3-0). USC has covered the spread two times this season when favored by at least 2.5 points. In the five games as the moneyline favorite, USC has recorded a 4-1 record. Michigan has a pair of wins against the spread so far this season (2-3-0). When Michigan is an underdog of 2.5 points or more, it has have yet to cover the spread. Michigan has been listed as an underdog on the moneyline in one game so far this season, and failed to pick up the victory.

USC vs. Michigan recent stats and trends

USC Trojans

• USC is winless against the spread (0-3) and 2-1 overall over its last three contests.
• USC and its opponents have hit the over two times in those games.
• The past three USC games averaged 1.8 more points (58.8) than this matchup’s point total.

Michigan Wolverines

• Michigan is 2-1 against the spread and 2-1 overall during its last three contests.
• Michigan and its opponents have hit the over twice in those games.
• Michigan’s last three games have ended with an average of 44.2 points scored. That’s 12.8 fewer points than this contest’s over/under.

USC vs. Michigan key players

USC Trojans

• Jayden Maiava has 1,587 yards passing for USC, completing 70.5% of his passes and throwing 11 touchdowns and one interception this season. He’s also helped out on the ground with 57 rushing yards (11.4 ypg) on 20 carries with four rushing touchdowns.
• The team’s top rusher, Waymond Jordan, has carried the ball 77 times for 537 yards (107.4 per game), scoring five times.
• Eli Sanders has carried the ball 47 times for 264 yards (52.8 per game) and two touchdowns while also racking up 115 yards through the air, scoring one time.
• Makai Lemon’s 589 yards as a receiver pace the team. He’s been targeted 43 times and has registered 35 catches and five touchdowns.
• Ja’Kobi Lane has put up a 278-yard season so far with one touchdown, hauling in 13 passes on 17 targets.
• Lake McRee has been the target of 18 passes and racked up 12 catches for 248 yards, an average of 49.6 yards per contest. He’s found the end zone one time through the air this season.
• Braylan Shelby leads the team with 3.5 sacks, and also has 3.0 TFL and five tackles.
• Eric Gentry, USC’s tackle leader, has 17 tackles, 4.0 TFL, and three sacks this year.
• Bishop Fitzgerald has a team-leading three interceptions to go along with nine tackles and three passes defended.

Michigan Wolverines

• Bryce Underwood leads Michigan with 1,003 yards on 77-of-130 passing with three touchdowns compared to one interception this season. He has chipped in with 181 rushing yards (36.2 ypg) on 27 carries while scoring three touchdowns on the ground.
• The team’s top rusher, Justice Haynes, has carried the ball 85 times for 654 yards (130.8 per game) with eight touchdowns.
• Jordan Marshall has racked up 233 yards on 45 carries with three touchdowns.
• Donaven McCulley paces his squad with 309 receiving yards on 19 catches with one touchdown.
• Semaj Morgan has put together a 187-yard season so far with one touchdown. He’s caught 16 passes on 24 targets.
• Marlin Klein has racked up 137 reciving yards (34.3 ypg) and one touchdown this season.
• Jaishawn Barham has 3.0 sacks to lead the team, and also has 4.0 TFL and 13 tackles.
• Michigan’s leading tackler, Jimmy Rolder, has 18 tackles, 1.0 TFL, and one sack this year.
• Cole Sullivan leads the team with two interceptions, while also collecting 14 tackles, 3.0 TFL, two sacks, and two passes defended.