The UConn Huskies (2-2) go on the road to play the Buffalo Bulls (2-2) at UB Stadium on Saturday, September 27, 2025.

The Huskies are favored, but by less than a touchdown (-3.5), versus the Bulls. The over/under for this matchup is 50.5 points.

Keep reading for our betting preview for this this matchup between the Huskies and the Bulls, and find all of our predictions here, too!

UConn vs. Buffalo betting lines

• Spread favorite: Huskies (-3.5)
• Moneyline: Huskies (-172), Bulls (+144)
• Total: 50.5 points

UConn vs. Buffalo betting info and stats

UConn has won once against the spread this season (1-2-1). UConn has covered the spread once this season when favored by at least 3.5 points. In three games as a moneyline favorite, UConn has gone 2-1. Buffalo has won twice against the spread so far this season (2-2-0). In the one game Buffalo has been an underdog by at least 3.5 points this season, it has covered the spread. Buffalo has played as the underdog on the moneyline in one game this season, and failed to pick up the victory.

UConn vs. Buffalo recent stats and trends

UConn Huskies

Buffalo Bulls

UConn vs. Buffalo key players

UConn Huskies

• Joe Fagnano has thrown for 1,046 yards (261.5 ypg) to lead UConn, completing 66.2% of his passes and collecting six touchdown passes this season.
• Cam Edwards has carried the ball 74 times for a team-high 500 yards on the ground and has found the end zone five times as a runner. He’s also tacked on two catches for 45 yards (22.5 per game).
• Jayden Brown has been handed the ball 16 times this year and racked up 159 yards (53.0 per game) with one touchdown.
• Skyler Bell’s team-leading 445 yards as a receiver have come on 36 receptions (out of 50 targets) with three touchdowns.
• Reymello Murphy has put up a 134-yard season so far with two touchdowns, hauling in 13 passes on 16 targets.
• John Neider has been the target of 10 passes and compiled six grabs for 89 yards, an average of 29.7 yards per contest.
• Bryun Parham, who leads the team in tackles and sacks, has racked up 5.5 sacks, 5.0 TFL and 28 tackles.
• D’Mon Brinson has picked off a team-leading one pass. He also has 17 tackles, 1.0 TFL, and one pass defended to his name.

Buffalo Bulls

• Ta’Quan Roberson has thrown for 662 yards (165.5 ypg) to lead Buffalo, completing 62.1% of his passes and recording five touchdown passes and two interceptions this season. He is also a playmaker on the ground, racking up 165 yards (41.3 ypg) on 31 carries with two touchdowns.
• The team’s top rusher, Al-Jay Henderson, has carried the ball 72 times for 274 yards (68.5 per game) with four touchdowns. He’s also caught 13 passes for 115 yards.
• Victor Snow has racked up 206 receiving yards on 16 catches to pace his squad so far this season while scoring three touchdowns as a receiver.
• Nik McMillan has caught 11 passes and compiled 154 receiving yards (38.5 per game) with one touchdown.
• Chance Morrow has racked up 119 reciving yards (39.7 ypg) and one touchdown this season.
• Saveon Brown leads the team with 2.0 sacks, and also has 3.0 TFL and 14 tackles.
• Buffalo’s leading tackler, Khalil Murdock, has 34 tackles, 3.0 TFL, and two sacks this year.
• Jalen McNair leads the team with one interception, while also collecting 19 tackles and one pass defended.