Cardinals vs. Reds Betting Lines, Odds, & Player Matchups June 22, 2025

Data Skrive
Data Skrive

The St. Louis Cardinals (41-35) and the Cincinnati Reds (39-37) take the field on Sunday at Busch Stadium, beginning at 2:15 p.m. ET. The Cardinals are favored on the moneyline (-114), while the Reds are -105 underdogs, even though they are favored against the spread (1.5) with +164 odds. St. Louis’ Miles Mikolas and Cincinnati’s Andrew Abbott pitch first for their squads in this matchup.

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Money Line

Cardinals to win vs Reds -114

Bet $20, Payout $37.54

Cardinals vs. Reds betting lines

  • Favorite: Cardinals (-114)
  • Underdog: Reds (-105)
  • Over/under: 9

Cardinals betting info, hitting leaders, & pitching

Cardinals betting info

  • The Cardinals have been favored on the moneyline 35 total times this season. They’ve gone 19-16 in those games.
  • St. Louis has gone 17-13 (winning 56.7% of its games) when playing as moneyline favorites of -114 or shorter.
  • Based on this contest’s moneyline, the Cardinals have an implied win probability of 53.3%.
  • In the 76 games in which bookmakers have set an over/under for St. Louis, it has combined with opponents to go over the total 40 times (40-33-3).
  • The Cardinals have a 43-33-0 record ATS this season.

Cardinals hitting info

  • Nolan Arenado has 11 doubles, a triple, nine home runs and 23 walks while batting .247.
  • Arenado’s home runs rank 88th in MLB and he ranks 56th in RBI in MLB.
  • Brendan Donovan’s .313 batting average is a team-high mark.
  • Donovan currently ranks 213th in homers and 132nd in RBI in the majors.
  • Willson Contreras has put up a team-best 10 home runs and 50 runs batted in.
  • Contreras has safely hit in two games in a row. During his last five outings he is hitting .167 with a double, two home runs, three walks and seven RBIs.
  • Lars Nootbaar has 13 doubles, nine home runs and 42 walks while hitting .229.
  • Nootbaar takes a three-game hitting streak into this game. During his last five outings he is hitting .211 with a double, a home run, three walks and three RBIs.

Cardinals pitching rankings

  • The 7.3 strikeouts per nine innings compiled by the Cardinals pitching staff ranks 29th in the majors.
  • St. Louis’ 3.94 team ERA ranks 18th across all MLB pitching staffs.
  • The Cardinals average MLB’s 15th-ranked WHIP (1.268).
  • Cardinals pitchers combine to surrender 62 home runs (0.8 per game), the third-fewest in baseball.
  • St. Louis struck out eight Reds batters while allowing four hits in a 6-1 win in its last game.

Reds betting info, hitting leaders, & pitching

Reds betting info

  • This season, the Reds have been the underdog 42 times and won 22, or 52.4%, of those games.
  • Cincinnati has entered 36 games this season as the underdog by -105 or more and is 18-18 in those contests.
  • The Reds have a 51.2% chance to win this game based on the implied probability of the moneyline.
  • Cincinnati’s games have gone over the total in 33 of its 75 chances.
  • The Reds are 39-36-0 against the spread in their 75 chances this season.

Reds hitting info

  • Elly De La Cruz is batting .263 this season with a team-high 16 home runs and 50 RBI.
  • De La Cruz’s home run total ranks 14th in MLB, and he is 14th in RBI.
  • TJ Friedl’s batting average of .290 leads all Cincinnati hitters this season.
  • Among all major league hitters, Friedl ranks 110th in homers and 115th in RBI.
  • Gavin Lux has 60 hits this season and a slash line of .270/.360/.383.
  • Jose Trevino has collected 42 hits this season and has an OBP of .349. He’s slugging .511 on the year.
  • Trevino has safely hit in three games in a row. In his last five games he is hitting .333 with two doubles, three walks and an RBI.

Reds pitching rankings

  • The Reds strike out 8.2 batters per nine innings as a pitching staff, 17th in MLB.
  • Cincinnati has pitched to a 3.91 ERA this season, which ranks 15th in baseball.
  • The Reds have a combined 1.227 WHIP as a pitching staff, 10th-lowest in MLB.
  • With 91 homers allowed, the Reds rank 22nd in the league at preventing long balls.
  • Cincinnati pitchers struck out 11 Cardinals hitters while allowing seven base hits in a 6-1 loss its last time out.
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Betting Guide

How Money Line Works?

Moneyline betting is by far the easiest way to place a sports wager. There are no point spreads to parse, no garbage-time free throws to ruin your betting day, and no last-minute meaningless touchdowns to take you from a winner to a loser.

How to Bet Odds

When we, as sports fans, learned our multiplication tables, we aced the number 7. Seven, 14, 21, 28, 35, 42 were easy because we all watched football on the weekends. Multiplication by sevens, then add a three, a six after a missed PAT.

How to Bet on NFL Games

Baseball is America’s pastime, but football is America’s crazed passion, with its weekly schedule of games, millions of television viewers across the country and the world, and the billion-dollar stadiums that serve as Sunday cathedrals in 32 American cities.

What is the Spread?

If you are a golfer or have ever played on a bowling team, think of a point spread like a handicap. It is a way for two teams of differing abilities to play each other on equal footing.  The better team, and the favorite in the game, gives a certain amount …