The SMU Mustangs (7-3) host an ACC battle against the Louisville Cardinals (7-3) on Saturday, November 22, 2025 at Gerald J. Ford Stadium.

The Cardinals are underdogs, but by less than a touchdown (+4.5), versus the Mustangs (with an over/under of 49.5 points).

Below you can find our betting primer for this this contest between the Mustangs and the Cardinals, and discover all of our predictions here, too!

SMU vs. Louisville betting lines

• Spread favorite: Mustangs (-4.5)
• Moneyline: Mustangs (-190), Cardinals (+158)
• Total: 49.5 points
• TV Channel: ESPN2
• Live Stream: Fubo

SMU vs. Louisville betting info and stats

SMU has an against-the-spread record of 4-5-0 this season. SMU has covered the spread twice this season when listed as the favorite by at least 4.5 points. SMU has won four of its six games played when favored on the moneyline this season. Louisville has won three games against the spread this season (3-7-0). When Louisville is an underdog of 4.5 points or more, it has always covered the spread (1-0 ATS). This is the second game this year Louisville is the moneyline underdog. The Cardinals won the first one.

SMU vs. Louisville recent stats and trends

SMU Mustangs

• SMU is 2-1 against the spread and 2-1 overall over its last three contests.
• The final combined score of the past three SMU games surpassed the set total once.
• The past three SMU games averaged 3.0 more points (52.5) than this matchup’s over/under.

Louisville Cardinals

• Louisville is 1-2 against the spread in its last three games, and has a 2-1 straight-up record in those contests.
• The final combined score of the last three Louisville games went over the set total one time.
• The last three Louisville games averaged 51.2 total points, 1.7 more points than this matchup’s point total.

SMU vs. Louisville key players

SMU Mustangs

• Kevin Jennings has 2,810 passing yards for SMU, completing 64.8% of his passes and collecting 21 touchdowns and nine interceptions this season.
• Tomarion Harden has racked up 612 yards on 133 carries while finding paydirt six times as a runner.
• Chris Johnson Jr. has carried the ball 46 times for 316 yards (39.5 per game) and three touchdowns while also racking up 163 yards through the air, scoring one time.
• Jordan Hudson’s team-leading 595 yards as a receiver have come on 42 receptions (out of 61 targets) with four touchdowns.
• Romello Brinson has grabbed 40 passes while averaging 58.2 yards per game and scoring three touchdowns.
• Yamir Knight has hauled in 37 receptions for 460 yards, an average of 46.0 yards per game. He’s scored four times as a receiver this season.
• Isaiah Smith has 8.0 sacks to pace the team, and also has 10.0 TFL and 34 tackles.
• Isaiah Nwokobia is the team’s leading tackler this year. He’s amassed 63 tackles and two interceptions.
• Ahmaad Moses leads the team with five interceptions, while also collecting 60 tackles, 4.0 TFL, one sack, and five passes defended.

Louisville Cardinals

• Miller Moss leads Louisville with 2,344 yards on 216-of-336 passing with 11 touchdowns compared to seven interceptions this season.
• The team’s top rusher, Isaac Brown, has carried the ball 91 times for 782 yards (97.8 per game) with five touchdowns.
• Keyjuan Brown has compiled 592 yards on 81 carries with six touchdowns.
• Chris Bell’s 871 receiving yards (87.1 yards per game) lead the team. He has 67 receptions on 104 targets with six touchdowns.
• Caullin Lacy has caught 52 passes and compiled 542 receiving yards (54.2 per game) with two touchdowns.
• Jaleel Skinner’s 25 targets have resulted in 18 catches for 178 yards and one touchdown.
• Wesley Bailey has racked up 5.0 sacks to pace the team, while also recording 4.0 TFL and 34 tackles.
• Louisville’s top-tackler, TJ Quinn, has 62 tackles, 3.0 TFL, one sack, and two interceptions this year.
• Antonio Watts leads the team with three interceptions, while also recording 37 tackles, 5.0 TFL, 2.5 sacks, and three passes defended.