Giants vs. Diamondbacks Betting Lines, Odds, & Player Matchups September 10, 2025

Data Skrive
Data Skrive

The San Francisco Giants (73-71) and the Arizona Diamondbacks (72-73) square off on Wednesday at 3:45 p.m. ET. The Giants are moneyline favorites (-144) against the underdog Diamondbacks (+121). San Francisco has Carson Seymour starting, and Arizona will send out Eduardo Rodriguez.

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Odds to Win

Giants to win vs Diamondbacks -144

Bet $20, Payout $33.89

Giants vs. Diamondbacks betting lines

  • Favorite: Giants (-144)
  • Underdog: Diamondbacks (+121)
  • Over/under: 7.5

Giants betting info, hitting leaders, & pitching

Giants betting info

  • The Giants have won 45 of the 84 games they were listed as the moneyline favorite this season (53.6%).
  • San Francisco has gone 29-23 (winning 55.8% of its games) when playing as moneyline favorites of -144 or shorter.
  • The implied moneyline probablility for this matchup gives the Giants a 59% chance to win.
  • In the 144 games in which bookmakers have set an over/under for San Francisco, it has combined with opponents to go over the total 67 times (67-69-8).
  • The Giants have a 67-77-0 record against the spread this season (covering 46.5% of the time).

Giants hitting info

  • Rafael Devers has a team-best 31 home runs and 100 runs batted in.
  • Devers’ home runs rank 11th in MLB and he ranks seventh in RBI in MLB.
  • Jung Hoo Lee’s .271 batting average leads his team.
  • Lee ranks 225th in homers and 144th in RBI among batters in MLB play.
  • Willy Adames is hitting .230 with 19 doubles, two triples, 27 home runs and 68 walks.
  • Heliot Ramos is hitting .266 with 23 doubles, a triple, 17 home runs and 45 walks.

Giants pitching rankings

  • The pitching staff for the Giants has a collective 8.6 K/9, which ranks 11th in the majors.
  • San Francisco has a 3.76 team ERA that ranks fifth across all MLB pitching staffs.
  • The Giants average MLB’s 16th-ranked WHIP (1.288).
  • Giants pitchers combine to allow 124 home runs (0.9 per game), the least in baseball.
  • In its 11-5 win last time out, San Francisco struck out 10 Diamondbacks batters while allowing eight hits.

Diamondbacks betting info, hitting leaders, & pitching

Diamondbacks betting info

  • This season, the Diamondbacks have been the underdog 60 times and won 29, or 48.3%, of those games.
  • This season, Arizona has won 16 of its 26 games, or 61.5%, when it’s the underdog by at least +121 on the moneyline.
  • The bookmakers’ moneyline implies a 45.2% chance of a victory for the Diamondbacks.
  • Games involving Arizona have gone over the total set by sportsbooks in 69 of 144 chances this season.
  • The Diamondbacks are 73-71-0 against the spread in their 144 chances this season.

Diamondbacks hitting info

  • Geraldo Perdomo leads Arizona in runs batted in with 91 and has a batting average of .281.
  • In all of Major League Baseball, Perdomo ranks 96th in home runs and 15th in RBI.
  • Corbin Carroll’s 30 home runs are most among Arizona batters. He’s driven in 74 runs this season while slugging .554.
  • Carroll is 12th overall in home runs and 48th in RBI this season.
  • Ketel Marte leads Arizona with a .287 batting average while slugging 25 homers and driving in 64 runs.
  • Gabriel Moreno is batting .283 with an OBP of .337 and a slugging percentage of .448 this season.
  • Moreno has hit safely in two straight games. During his last five outings he is hitting .357 with a double, a home run, three walks and three RBIs.

Diamondbacks pitching rankings

  • The Diamondbacks have an 8.0 K/9 this season as a pitching staff, which ranks 22nd in the big leagues.
  • Arizona has the 23rd-ranked ERA (4.48) in the majors this season.
  • The Diamondbacks have a combined WHIP of 1.326 as a pitching staff, which ranks 21st in MLB.
  • The Diamondbacks have given up the 17th-fewest long balls so far this season with 172 home runs allowed.
  • Last time out, Arizona fell to the Giants 11-5. Its pitchers compiled six strikeouts and 12 hits allowed.
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