The Purdue Boilermakers (1-0) face an FCS opponent, the Southern Illinois Salukis (1-0), on Saturday, September 6, 2025 at Ross-Ade Stadium.

The Salukis are expected to lose by at least two touchdowns (currently +20.5) versus the Boilermakers (with an over/under of 52.5 points).

Keep reading to check out our betting primer for this this game between the Boilermakers and the Salukis, and discover all of our expert predictions here, too!

Purdue vs. Southern Illinois betting lines

• Spread favorite: Boilermakers (-20.5)
• Moneyline: Boilermakers (-1176), Salukis (+732)
• Total: 52.5 points
• TV Channel: Big Ten Network Alternate
• Live Stream: Fubo

Purdue vs. Southern Illinois betting info and stats

• Purdue had two wins against the spread last year.
• Purdue had seven of its 11 games hit the over last season.
• Against the spread, Southern Illinois was 4-8-0 last year.
• Southern Illinois didn’t have a win ATS (0-1) as 20.5-point or larger underdogs last season.
• There were nine Southern Illinois games (out of 12) that went over the total last year.

Purdue vs. Southern Illinois key players

Purdue Boilermakers

• Hudson Card had a passing stat line last season of 1,641 yards with a 58.1% completion rate (144-for-248), nine touchdowns, seven interceptions, and an average of 164.1 yards per game.
• Last year, Devin Mockobee rushed for 687 yards on 138 attempts (57.3 yards per game) and scored four times.
• Reggie Love III put up 372 rushing yards on 83 carries and two touchdowns last season.
• In the previous year, Max Klare grabbed 51 passes (on 79 targets) for 685 yards (57.1 per game). He also found the end zone four times.
• Jahmal Edrine also impressed receiving last year. He bagged 23 receptions for 365 yards and two touchdowns. He was targeted 47 times.
• Jaron Tibbs’ stat line last season: 305 receiving yards, 25 catches, two touchdowns, on 43 targets.
• Last season Kydran Jenkins stacked up 7.0 sacks, 8.0 TFL and 68 tackles.
• Last season Dillon Thieneman grabbed 82 tackles, 4.0 TFL, and one sack.
• Kyndrich Breedlove collected three interceptions while adding 32 tackles, 1.0 TFL, and three passes defended last year.

Southern Illinois Salukis

• Jake Curry connected on 55.5% of his passes and threw for 928 yards and three touchdowns last season. Curry also helped on the ground, tallying three touchdowns on 14.5 yards per game.
• Jerrian Parker racked up one rushing touchdown on 23.4 yards per game last season.
• DJ Williams ran for four touchdowns on 243 yards a year ago.
• Keontez Lewis averaged 79.0 yards on 4.5 receptions per game and racked up five receiving touchdowns in 2024.
• Allen Middleton collected two touchdowns and had 418 receiving yards (34.8 ypg) in 2024.
• Nah’Shawn Hezekiah caught 25 passes on his way to 398 receiving yards and three touchdowns a season ago.
• Last year Ben Bogle racked up 5.5 sacks, 1.0 TFL, eight tackles, and two interceptions.
• Colin Bohanek had an impressive defensive performance last season with 12 tackles and 0.5 sacks.
• Desman Hearns racked up two interceptions in addition to three tackles and 1.0 TFL a year ago.