The Pittsburgh Panthers (2-2) and the Boston College Eagles (1-3) square off on Saturday, October 4, 2025 at Acrisure Stadium in a battle of ACC foes.

The Panthers are favored, but by less than a touchdown (-6.5), against the Eagles. The over/under for this matchup is 56.5 points.

Keep reading for our betting preview for this this contest between the Panthers and the Eagles, and discover all of our expert picks here, too!

Pittsburgh vs. Boston College betting lines

• Spread favorite: Panthers (-6.5)
• Moneyline: Panthers (-236), Eagles (+193)
• Total: 56.5 points
• TV Channel: ACC Network
• Live Stream: Fubo

Pittsburgh vs. Boston College betting info and stats

Pittsburgh has won twice against the spread this season (2-2-0). Pittsburgh has covered the spread twice this season when favored by at least 6.5 points. In three games as the moneyline favorite, Pittsburgh is 2-1. Boston College, in four games with a set spread so far this season, has gone 2-2-0 against the spread. This will be the second time this year Boston College is an underdog on the moneyline. The Eagles lost the first one.

Pittsburgh vs. Boston College recent stats and trends

Pittsburgh Panthers

Boston College Eagles

Pittsburgh vs. Boston College key players

Pittsburgh Panthers

• Eli Holstein has thrown for 1,050 yards (262.5 ypg) to lead Pittsburgh, completing 63.2% of his passes and recording 11 touchdown passes compared to five interceptions this season. He’s also figured in the ground game with 69 rushing yards on 32 carries with one rushing touchdown.
• Desmond Reid has racked up 142 yards on 24 carries while finding the end zone one time. He’s also caught six passes for 71 yards (23.7 per game).
• Juelz Goff has been handed the ball 28 times this year and racked up 116 yards (29.0 per game) with two touchdowns.
• Raphael Williams’ team-leading 342 yards as a receiver have come on 17 catches (out of 27 targets) with four touchdowns.
• Cataurus Hicks has caught 11 passes for 197 yards (49.3 yards per game) and three touchdowns this year.
• Bryce Yates has hauled in four receptions for 143 yards, an average of 71.5 yards per game. He’s scored one time as a receiver this season.
• Blaine Spires paces the team with 2.5 sacks, and also has 4.0 TFL and 12 tackles.
• Rasheem Biles, Pittsburgh’s top tackler, has 40 tackles, 5.0 TFL, one sack, and one interception this year.
• Braylan Lovelace has picked off a team-high one pass. He also has 29 tackles, 3.0 TFL, and one pass defended to his name.

Boston College Eagles

• Dylan Lonergan leads Boston College with 1,188 yards on 111-of-160 passing with nine touchdowns compared to three interceptions this season.
• The team’s top rusher, Turbo Richard, has carried the ball 58 times for 329 yards (82.3 per game) with four touchdowns. He’s also caught 16 passes for 168 yards and two touchdowns.
• Jordan McDonald has run for 50 yards across 17 carries, scoring one touchdown.
• Lewis Bond has totaled 36 catches this season and his team-high yardage total sits at 352 (88.0 yards per game). He’s been targeted 47 times.
• Reed Harris has caught 15 passes and compiled 250 receiving yards (62.5 per game) with two touchdowns.
• Jeremiah Franklin’s 31 targets have resulted in 20 grabs for 189 yards and one touchdown.
• Micah Amedee leads the team with 1.0 sack, and also has 1.0 TFL.
• KP Price, Boston College’s tackle leader, has 11 tackles this year.
• Omar Thornton has picked off a team-high one pass. He also has 10 tackles, 3.0 TFL, one sack, and one pass defended to his name.