Pirates vs. Orioles Betting Lines, Odds, & Player Matchups September 10, 2025

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Data Skrive

Sportsbooks give the Pittsburgh Pirates (64-80) the edge, -143 on the moneyline, to halt their three-game losing streak when they take on the Baltimore Orioles (66-77), at +120, on Wednesday at 6:35 p.m. ET. Pittsburgh has Paul Skenes starting, while Baltimore will counter with Tyler Wells.

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Money Line

Pirates to win vs Orioles -143

Bet $20, Payout $33.99

Pirates vs. Orioles betting lines

  • Favorite: Pirates (-143)
  • Underdog: Orioles (+120)
  • Over/under: 7.5

Pirates betting info, hitting leaders, & pitching

Pirates betting info

  • The Pirates are 20-19 in games they were favored on the moneyline (winning 51.3% of those games).
  • Pittsburgh has gone 10-7 (winning 58.8% of its games) when it has played as moneyline favorites of -143 or shorter.
  • The Pirates have an implied moneyline win probability of 58.8% in this game.
  • In the 143 games in which bookmakers have set an over/under for Pittsburgh, it has combined with opponents to go over the total 60 times (60-78-5).
  • The Pirates have a 77-66-0 record against the spread this season (covering 53.8% of the time).

Pirates hitting info

  • Bryan Reynolds has put up a team-best batting average of .248 and paces the Pirates in runs batted in (70).
  • Among all batters in MLB play, Reynolds’ home run total ranks 123rd and his RBI tally ranks 60th.
  • Reynolds takes a two-game hitting streak into this matchup. During his last five outings he is hitting .375 with a double, a home run, three walks and two RBIs.
  • Oneil Cruz has hit 19 home runs to lead his team.
  • Cruz ranks 72nd in homers and 114th in RBI this season.
  • Andrew McCutchen has 22 doubles, 13 home runs and 61 walks while batting .244.
  • Tommy Pham has 17 doubles, a triple, eight home runs and 39 walks while hitting .261.

Pirates pitching rankings

  • The pitching staff for the Pirates has a collective 8.1 K/9, which ranks 21st in MLB.
  • Pittsburgh has the 13th-ranked team ERA across all MLB pitching staffs (3.92).
  • Pitchers for the Pirates combine for the No. 6-ranked WHIP in the majors (1.227).
  • The Pirates surrender the third-fewest home runs in baseball (137 total, one per game).
  • Pittsburgh struck out nine Brewers batters while giving up 14 hits in a 10-2 loss in its last game.

Orioles betting info, hitting leaders, & pitching

Orioles betting info

  • The Orioles have been underdogs in 80 games this season and won 37 (46.2%) of those contests.
  • Baltimore has a record of 14-19, a 42.4% win rate, when it’s set as an underdog of +120 or more by oddsmakers this season.
  • Bookmakers have implied with the moneyline set for this matchup that the Orioles have a 45.5% chance to win.
  • Baltimore and its opponents have hit the over in 60 of its 143 games with a total this season.
  • The Orioles have an ATS record of 69-74-0 in 143 games with a spread this season.

Orioles hitting info

  • Gunnar Henderson is batting .274 with 61 RBI, both of which are best among Baltimore hitters this season.
  • In all of Major League Baseball, Henderson is 107th in homers and 96th in RBI.
  • Jackson Holliday is slugging .394 this season, with a team-best 17 homers while driving in 53 runs.
  • Holliday ranks 96th in home runs and 135th in RBI among all batters in the major leagues.
  • Ryan Mountcastle has 75 hits this season and a slash line of .260/.299/.374.
  • Colton Cowser has collected 57 hits this season and has an OBP of .273. He’s slugging .396 on the year.

Orioles pitching rankings

  • The Orioles have an 8.3 K/9 this season as a pitching staff, which ranks 19th in the majors.
  • Baltimore pitchers have a combined ERA of 4.66 ERA this year, which ranks 25th in MLB.
  • The Orioles have a combined WHIP of 1.378 as a pitching staff, which is fourth-worst in baseball this season.
  • The Orioles have allowed the fourth-most home runs this season with 194, or 1.4 per game.
  • Baltimore suffered a 5-2 defeat in its most recent game, as its pitchers struck out six Dodgers batters while allowing 10 hits.
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Betting Guide

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