The No. 20 USC Trojans (5-1) visit the No. 13 Notre Dame Fighting Irish (4-2) at Notre Dame Stadium on Saturday, October 18, 2025.

The Fighting Irish are expected to win by double digits (currently -10.5) against the Trojans. The over/under for this matchup is 60.5 points.

Read on for our betting primer for this this game between the Fighting Irish and the Trojans, and find all of our betting picks here, too!

Notre Dame vs. USC betting lines

• Spread favorite: Fighting Irish (-10.5)
• Moneyline: Fighting Irish (-386), Trojans (+304)
• Total: 60.5 points
• TV Channel: NBC (WBGH-Binghamton, NY)
• Live Stream: Fubo

Notre Dame vs. USC betting info and stats

Notre Dame has won three games against the spread this season (3-3-0). Notre Dame has covered the spread two times when the favorite by at least 10.5 points (a 2-1 ATS record). Notre Dame has been favored on the moneyline in six games this season, and it has recorded a 4-2 record in those outings. USC is 3-3-0 against the spread this season. USC has not played a game as an underdog on the moneyline yet this season.

Notre Dame vs. USC recent stats and trends

Notre Dame Fighting Irish

• Notre Dame is 2-1 against the spread in its last three games, and has a 3-0 straight-up record in those matchups.
• The final combined score of the past three Notre Dame games went over the set total one time.
• Notre Dame’s past three outings have ended with an average of 62.2 points scored. That’s 1.7 more points than this contest’s over/under.

USC Trojans

• USC is 1-2 against the spread over its past three games, and has a 3-0 straight-up record in those contests.
• USC and its opponents have combined to hit the over twice in those games.
• The last three USC games averaged 58.0 total points, 2.5 fewer points than this matchup’s point total.

Notre Dame vs. USC key players

Notre Dame Fighting Irish

• CJ Carr has 1,622 pass yards for Notre Dame, completing 66.5% of his passes and throwing 13 touchdowns and three interceptions this season.
• Jeremiyah Love has 530 rushing yards on 100 carries with eight touchdowns. He’s also added 14 catches for 160 yards (32.0 per game) and three touchdowns via the passing game.
• Jadarian Price has been handed the ball 63 times this year and racked up 422 yards (70.3 per game) with seven touchdowns. He’s also contributed in the passing game with one grab for 35 yards and one touchdown.
• Jordan Faison’s team-high 376 yards as a receiver have come on 29 catches (out of 37 targets) with two touchdowns.
• Eli Raridon has caught 20 passes while averaging 68.4 yards per game.
• Malachi Fields has a total of 339 receiving yards so far this year, grabbing 18 passes and scoring two touchdowns.
• Boubacar Traore paces the team with 4.5 sacks, and also has 5.0 TFL and 23 tackles.
• Drayk Bowen, Notre Dame’s top tackler, has 26 tackles and one sack this year.
• Leonard Moore has a team-high three interceptions to go along with 12 tackles and three passes defended.

USC Trojans

• Jayden Maiava leads USC with 1,852 yards on 123-of-171 passing with 13 touchdowns compared to two interceptions this season.
• Waymond Jordan has rushed for 576 yards on 88 carries so far this year while scoring five times on the ground.
• King Miller has totaled 310 yards on 29 carries with three touchdowns.
• Makai Lemon’s 682 receiving yards (113.7 yards per game) lead the team. He has 44 catches on 53 targets with six touchdowns.
• Ja’Kobi Lane has recorded 313 receiving yards (62.6 yards per game) and two touchdowns on 18 receptions.
• Lake McRee’s 21 targets have resulted in 14 receptions for 289 yards and one touchdown.
• Braylan Shelby has collected 3.5 sacks to pace the team, while also recording 3.0 TFL and six tackles.
• Eric Gentry is the team’s tackle leader this year. He’s racked up 23 tackles, 4.0 TFL, and three sacks.
• Bishop Fitzgerald has a team-leading five interceptions to go along with 14 tackles, 1.0 TFL, one sack, and five passes defended.