The Nebraska Cornhuskers (3-1) and the Michigan State Spartans (3-1) play on Saturday, October 4, 2025 at Memorial Stadium (Lincoln, NE) in a battle of Big Ten opponents.

The Cornhuskers are double-digit favorites (currently -11.5) in their matchup against the Spartans, with the over/under at 48.5 points. (In terms of the moneyline, the Cornhuskers are -461 and the Spartans are +352.)

Keep reading for our betting primer for this this game between the Cornhuskers and the Spartans, and find all of our predictions here, too!

Nebraska vs. Michigan State betting lines

• Spread favorite: Cornhuskers (-11.5)
• Moneyline: Cornhuskers (-461), Spartans (+352)
• Total: 48.5 points
• TV Channel: FOX Sports 1
• Live Stream: Fubo

Nebraska vs. Michigan State betting info and stats

Nebraska has won two games against the spread so far this season (2-2-0). Nebraska has always covered the spread when the favorite by at least 11.5 points (a 2-0 ATS record). Nebraska has been favored on the moneyline three times this season, winning every game. Michigan State has a single win against the spread so far this season (1-3-0). In the one game Michigan State has been an underdog by at least 11.5 points this season, it has covered the spread. This will be the second time this year Michigan State is the moneyline underdog. The Spartans lost the first one.

Nebraska vs. Michigan State recent stats and trends

Nebraska Cornhuskers

Michigan State Spartans

Nebraska vs. Michigan State key players

Nebraska Cornhuskers

• Dylan Raiola has racked up 1,139 yards (284.8 ypg) on 102-of-135 passing with 11 touchdowns compared to one interception this season.
• Emmett Johnson has 391 rushing yards on 71 carries with four touchdowns. He’s also tacked on 16 catches for 73 yards (18.3 per game) and one touchdown through the air.
• Kwinten Ives has carried the ball 16 times for 119 yards (59.5 per game) and two touchdowns while also racking up 43 yards through the air.
• Jacory Barney Jr. has hauled in 21 catches for 301 yards (75.3 yards per game) to lead the team so far this season. He’s found the end zone three times as a receiver.
• Dane Key has put up a 226-yard season so far with three touchdowns, reeling in 16 passes on 22 targets.
• Nyziah Hunter has been the target of 23 passes and racked up 13 grabs for 197 yards, an average of 49.3 yards per contest. He’s found the end zone one time through the air this season.
• Dasan McCullough has 2.0 sacks to lead the team, and also has 3.0 TFL and seven tackles.
• Javin Wright is the team’s tackle leader this year. He’s collected 16 tackles and 2.0 TFL.
• Malcolm Hartzog has a team-high one interception to go along with one pass defended.

Michigan State Spartans

• Aidan Chiles has thrown for 868 yards on 70-of-102 passing with nine touchdowns and one interception this season. He has chipped on the ground, as well, with 154 yards and two rushing touchdowns.
• Makhi Frazier has rushed 57 times for 267 yards, with two touchdowns.
• Omari Kelly has registered 21 catches this season and his team-high yardage total sits at 317 (79.3 yards per game). He’s been targeted 28 times and has one touchdown.
• Nick Marsh has totaled 222 receiving yards (55.5 yards per game) and three touchdowns on 18 receptions.
• Chrishon McCray’s seven catches (on 11 targets) have netted him 128 yards (32.0 ypg) and one touchdown.
• Anelu Lafaele has racked up 2.0 sacks to lead the team, while also recording 1.0 TFL and six tackles.
• Jordan Hall, Michigan State’s leading tackler, has 28 tackles, 3.0 TFL, and two sacks this year.
• Armorion Smith has a team-high one interception to go along with 12 tackles and one pass defended.