The Louisville Cardinals (0-0) play an FCS opponent, the Eastern Kentucky Colonels (0-0), on Saturday, August 30, 2025 at L&N Federal Credit Union Stadium.

The Cardinals are very big favorites (currently -37.5) in their matchup against the Colonels, with the over/under at 56.5 points. (On the moneyline, the Cardinals are -3226 and the Colonels are +1400.)

Keep reading to check out our betting preview for this this game between the Cardinals and the Colonels, and discover all of our expert picks here, too!

Louisville vs. Eastern Kentucky betting lines

• Spread favorite: Cardinals (-37.5)
• Moneyline: Cardinals (-3226), Colonels (+1400)
• Total: 56.5 points
• TV Channel: ACC Network
• Live Stream: Fubo

Louisville vs. Eastern Kentucky betting info and stats

• Louisville’s record against the spread last year was 6-6-0.
• In 12 Louisville games last year, eight hit the over.
• Eastern Kentucky had seven wins in 13 games against the spread last year.
• In 13 Eastern Kentucky games last year, four of them hit the over.

Louisville vs. Eastern Kentucky key players

Louisville Cardinals

• Tyler Shough recorded a passing stat line last year of 3,195 yards with a 62.7% completion rate (244-for-389), 23 touchdowns, six interceptions, and an average of 266.3 yards per game.
• Last year, Isaac Brown rushed for 1,173 yards on 165 carries (90.2 yards per game) and scored 11 times.
• Duke Watson churned out 597 yards on 67 carries (49.8 yards per game), with seven rushing touchdowns last year.
• In the previous year, Ja’Corey Brooks grabbed 61 passes (on 98 targets) for 1,013 yards (92.1 per game). He also found the end zone nine times.
• Chris Bell also impressed receiving last season. He collected 43 receptions for 737 yards and four touchdowns. He was targeted 67 times.
• Mark Redman’s stat line last year: 251 receiving yards, 23 catches, three touchdowns, on 35 targets.
• Ashton Gillotte did his thing last season with an incredible stat line of 4.5 sacks, 8.0 TFL and 36 tackles.
• TJ Quinn was a wrecking ball on the field, collecting 77 tackles, 1.0 TFL, and 1.5 sacks last year.
• Corey Thornton intercepted two passes last year while also totaling 36 tackles and two passes defended.

Eastern Kentucky Colonels

• Matt Morrissey completed 57.4% of his passes to throw for 2,088 yards and 14 touchdowns last season. He also helped on the ground, accumulating three touchdowns while racking up 295 yards.
• Joshua Carter compiled 1,258 rushing yards and 14 touchdowns on the ground in addition to 224 receiving yards and zero touchdowns through the air during last year’s campaign.
• Brayden Latham rushed for 662 yards and three touchdowns last season.
• Marcus Calwise Jr. averaged 43.8 yards on 3.5 receptions per game and racked up five receiving touchdowns in 2024.
• Dequan Stanley grabbed five touchdowns and had 372 receiving yards (41.3 ypg) in 2024.
• Last year Gabe Stephens put pressure on opposing quarterbacks with 4.5 sacks, and added eight tackles.
• Sam Robertson was a force on the field last season with 17 tackles.
• Mike Smith Jr. racked up four interceptions in addition to eight tackles a year ago.