Big 12 opponents match up when the Kansas Jayhawks (4-4) and the Oklahoma State Cowboys (1-7) play on Saturday, November 1, 2025 at David Booth Kansas Memorial Stadium.

The Cowboys are expected to lose by at least two touchdowns (currently +24.5) against the Jayhawks (with an over/under of 55 points).

Below you can find our preview for this this game between the Jayhawks and the Cowboys, and find all of our predictions here, too!

Kansas vs. Oklahoma State betting lines

• Spread favorite: Jayhawks (-24.5)
• Moneyline: Jayhawks (-3125), Cowboys (+1260)
• Total: 55 points

Kansas vs. Oklahoma State betting info and stats

Kansas has three wins against the spread so far this season (3-5-0). Kansas is winless ATS (0-1) when favorites by at least 24.5 points. Kansas has won three of its five games played as the moneyline favorite this season. Oklahoma State, in eight games with a set spread so far this season, is 1-7-0 against the spread. When Oklahoma State is an underdog of 24.5 points or more, it has have yet to cover the spread. Oklahoma State has played as the underdog on the moneyline five times this season, losing each game.

Kansas vs. Oklahoma State recent stats and trends

Kansas Jayhawks

• Kansas is 1-2 against the spread over its past three games, and has a 1-2 straight-up record in those contests.
• Twice in those three games, the final combined score has exceeded the set total.
• The past three Kansas games averaged 1.2 more points (56.2) than this matchup’s over/under.

Oklahoma State Cowboys

• Oklahoma State has not covered a spread (0-3) while going 1-2 overall during its last three matchups.
• Two times in those three games, the final combined score has gone over the set total.
• The past three Oklahoma State games averaged 1.0 fewer point (54.0) than this matchup’s over/under.

Kansas vs. Oklahoma State key players

Kansas Jayhawks

• Jalon Daniels has recorded 1,881 yards (235.1 ypg) on 147-of-221 passing with 18 touchdowns compared to three interceptions this season. In addition, he’s added 235 rushing yards (29.4 ypg) on 82 carries while scoring two touchdowns on the ground.
• Leshon Williams has 319 rushing yards on 57 carries with five touchdowns. He’s also added three catches for 65 yards (16.3 per game) and two touchdowns via the passing game.
• Daniel Hishaw Jr. has carried the ball 62 times for 298 yards (49.7 per game) and two touchdowns.
• Emmanuel Henderson Jr. has hauled in 34 catches for 554 yards (69.3 yards per game) to lead the team so far this season. He’s found the end zone four times as a receiver.
• Cam Pickett has put up a 349-yard season so far with three touchdowns, reeling in 30 passes on 36 targets.
• Boden Groen’s 27 receptions are good enough for 327 yards and three touchdowns.
• Leroy Harris III has 4.5 sacks to pace the team, and also has 4.0 TFL and 14 tackles.
• Trey Lathan is the team’s top-tackler this year. He’s amassed 53 tackles, 4.0 TFL, 1.5 sacks, and one interception.
• Lyrik Rawls leads the team with one interception, while also putting up 48 tackles, 1.0 TFL, and one pass defended.

Oklahoma State Cowboys

• Zane Flores has recored 696 passing yards, or 139.2 per game, so far this season. He has completed 55% of his passes. He’s also contributed on the ground with 22.8 rushing yards per game while scoring as a runner one time.
• Rodney Fields Jr.’s team-high 420 rushing yards have come on 76 carries, with one touchdown. He also leads the team with 215 receiving yards (43.0 per game) on 19 catches with one touchdown.
• Trent Howland has collected 166 yards (on 41 attempts) with two touchdowns.
• Gavin Freeman paces his team with 280 receiving yards on 29 catches with two touchdowns.
• Shamar Rigby has 13 receptions (on 24 targets) for a total of 219 yards (27.4 yards per game) this year.
• Wendell Gregory has racked up 3.0 sacks to lead the team, while also recording 10.0 TFL and 22 tackles.
• Parker Robertson, Oklahoma State’s leading tackler, has 51 tackles, 5.0 TFL, and one interception this year.
• Kale Smith has a team-leading one interception to go along with 19 tackles, 1.0 TFL, and one pass defended.