James Cook will hope to make a difference for the Buffalo Bills when they play the Atlanta Falcons at 7:15 p.m. ET on Monday in Week 6 of the 2025 NFL season. In this article, we dig into all of Cook’s prop bets set for this matchup, and examine the stats and insights to figure out the best bets and top trends before kickoff.

James Cook Prop Lines

• Matchup: Buffalo Bills at Atlanta Falcons
• Time: 7:15 p.m. ET
• Date: October 13, 2025
• Rushing yards prop: Over 71.5 (-110)
• Receiving yards prop: Over 13.5 (-114)

James Cook Stats and Trends

• Cook leads the team with 450 yards on 90 rushes (90.0 ypg). He’s scored five rushing TDs.
• Cook runs for 90.0 yards per game, which is better than Monday’s over/under of 71.5.
• Cook has put up more than 71.5 yards on the ground in three of five games.
• He has bettered his average rushing yards over/under on the season (68.3) by 21.7 yards.
• Cook has gone over his rushing yards prop bet three times (in five opportunities) this year.
• He has recorded multiple rushing TDs once this season. He has scored on the ground in four games in all.
• Cook has also caught 12 balls for 89 yards (17.8 ypg).

Recent Performances vs. the Falcons

Bills Away Splits (Last Season)

• On the road last year, the Bills averaged fewer points (27.9 per game) than overall (30.9). They also conceded more (25.2 per game) than overall (21.6).
• The Bills accumulated more yards in away games (360.1 per game) than they did overall (359.1), but they also allowed more (386.3 per game) than overall (341.5).
• On the road last season, the Bills accumulated fewer passing yards (224.9 per game) than overall (227.9). They also conceded more passing yards (270.8 per game) than overall (226.1).
• The Bills accumulated 135.2 rushing yards per game on the road (4.0 more than overall), and allowed 115.6 on the road (0.1 more than overall).
• The Bills converted 40.9% of third downs in road games in 2024 (3.2% less than overall), and conceded on 45.5% of third downs on the road (1.7% more than overall).