The Iowa State Cyclones (6-4) and the Kansas Jayhawks (5-5) square off on Saturday, November 22, 2025 at Jack Trice Stadium in a battle of Big 12 opponents.

The Cyclones are the favorites (-3.5) in their game versus the Jayhawks, with the over/under being 55.5 points. (In terms of the moneyline, the Cyclones are -165 and the Jayhawks are +138.)

Below you can find our preview for this this matchup between the Cyclones and the Jayhawks, and discover all of our predictions here, too!

Iowa State vs. Kansas betting lines

• Spread favorite: Cyclones (-3.5)
• Moneyline: Cyclones (-165), Jayhawks (+138)
• Total: 55.5 points
• TV Channel: FOX Sports 1
• Live Stream: Fubo

Iowa State vs. Kansas betting info and stats

Iowa State has an against-the-spread record of 4-5-1 this season. Iowa State has covered the spread two times this season when favored by at least 3.5 points. Iowa State has been listed as moneyline favorites seven times this season, and has put up a 4-3 record in those contests. Kansas has four wins against the spread through 10 opportunities so far this season (4-6-0). When Kansas is the underdog by 3.5 points or more, it has covered the spread once (1-2 ATS). Kansas has played as an underdog on the moneyline three times this season, losing each game.

Iowa State vs. Kansas recent stats and trends

Iowa State Cyclones

• Iowa State has covered the spread once in its past three matchups while putting together a 1-2 record straight-up in those games.
• Iowa State and its opponents have hit the over once in those games.
• The last three Iowa State games averaged 51.8 total points, 3.7 fewer points than this matchup’s point total.

Kansas Jayhawks

• Kansas has covered the spread once in its past three matchups while putting up a 1-2 record straight-up in those games.
• Kansas and its opponents have combined to hit the over two times in those games.
• The past three Kansas games averaged 0.2 more points (55.7) than this matchup’s point total.

Iowa State vs. Kansas key players

Iowa State Cyclones

• Rocco Becht has thrown for 2,230 yards (223.0 ypg) to lead Iowa State, completing 59.9% of his passes and tossing 12 touchdown passes compared to nine interceptions this season.
• Carson Hansen has racked up 721 yards on 141 carries while finding the end zone five times.
• This season, Abu Sama III has carried the ball 110 times for 588 yards (58.8 per game) and four touchdowns.
• Brett Eskildsen’s team-high 434 yards as a receiver have come on 23 catches (out of 43 targets) with three touchdowns.
• Benjamin Brahmer has hauled in 33 receptions totaling 388 yards, finding the end zone five times as a receiver so far this campaign.
• Chase Sowell has a total of 386 receiving yards so far this year, hauling in 26 passes and scoring one touchdown.
• Tamatoa McDonough has 2.0 sacks to lead the team, and also has 2.0 TFL and 22 tackles.
• Iowa State’s top-tackler, Marcus Neal, has 59 tackles, 8.0 TFL, one sack, and one interception this year.
• Jamison Patton leads the team with two interceptions, while also collecting 43 tackles, 1.0 TFL, and two passes defended.

Kansas Jayhawks

• Jalon Daniels leads Kansas with 2,190 yards on 175-of-269 passing with 21 touchdowns compared to three interceptions this season. He has chipped in with 337 rushing yards (33.7 ypg) on 102 carries while scoring three touchdowns on the ground.
• Daniel Hishaw Jr. has run the ball 94 times for 430 yards, with four touchdowns.
• Leshon Williams has collected 419 yards (on 78 attempts) with six touchdowns.
• Emmanuel Henderson Jr. has collected 41 receptions this season and his team-high yardage total sits at 638 (63.8 yards per game). He’s been targeted 68 times and has five touchdowns.
• Cam Pickett has 36 receptions (on 46 targets) for a total of 423 yards (42.3 yards per game) and three touchdowns this year.
• Boden Groen’s 31 grabs (on 39 targets) have netted him 374 yards (37.4 ypg) and four touchdowns.
• Leroy Harris III has collected 4.5 sacks to lead the team, while also picking up 5.0 TFL and 21 tackles.
• So far Trey Lathan leads the team in both tackles and interceptions. He has totaled 68 tackles, 4.0 TFL, 1.5 sacks, and one interception this season.