The No. 14 Iowa State Cyclones (4-0) and the Arizona Wildcats (3-0) play on Saturday, September 27, 2025 at Jack Trice Stadium in a battle of Big 12 opponents.

The Cyclones are the favorites (-5.5) in their game versus the Wildcats, with the over/under at 48.5 points. (In terms of the moneyline, the Cyclones are -210 and the Wildcats are +172.)

Below you can find our preview for this this contest between the Cyclones and the Wildcats, and find all of our predictions here, too!

Iowa State vs. Arizona betting lines

• Spread favorite: Cyclones (-5.5)
• Moneyline: Cyclones (-210), Wildcats (+172)
• Total: 48.5 points
• TV Channel: ESPN
• Live Stream: Fubo

Iowa State vs. Arizona betting info and stats

Iowa State has a pair of wins against the spread so far this season (2-1-1). Iowa State has covered the spread in one game when the favorite by at least 5.5 points (a 1-1 ATS record). In the three games favored on the moneyline, Iowa State has put up a 3-0 record. Arizona has not lost a game against the spread this season (2-0-0). Arizona has been listed as the underdog on the moneyline one time this season, and won that game.

Iowa State vs. Arizona key players

Iowa State Cyclones

• Rocco Becht has thrown for 860 yards (215.0 ypg) to lead Iowa State, completing 65% of his passes and tossing seven touchdown passes compared to one interception this season. He’s also figured in the ground game with 48 rushing yards on 27 carries with two rushing touchdowns.
• Carson Hansen has 252 rushing yards on 54 carries.
• This season, Abu Sama III has carried the ball 38 times for 182 yards (45.5 per game) and two touchdowns.
• Brett Eskildsen has hauled in seven catches for 162 yards (40.5 yards per game) to lead the team so far this season. He’s found the end zone one time as a receiver.
• Gabe Burkle has hauled in 10 passes while averaging 49.7 yards per game and scoring one touchdown.
• Xavier Townsend has a total of 132 receiving yards so far this year, grabbing seven passes.
• Tamatoa McDonough has 2.0 sacks to pace the team, and also has 2.0 TFL and nine tackles.
• Marcus Neal is the team’s tackle leader this year. He’s racked up 28 tackles, 4.0 TFL, and one sack.
• Tre Bell has picked off a team-high one pass. He also has nine tackles, 1.0 TFL, and one pass defended to his name.

Arizona Wildcats

• Noah Fifita has racked up 712 yards on 59% passing while collecting six touchdown passes with zero interceptions this season. He’s also rushed for 37 yards with three scores.
• Ismail Mahdi has run for 263 yards on 37 carries so far this year while scoring one time on the ground. He’s also added four catches, totaling 56 yards and one touchdown in the passing game.
• Quincy Craig has racked up 165 yards (on 18 attempts) with one touchdown.
• Jayin Whatley has racked up 237 receiving yards on 13 receptions to pace his squad so far this season while scoring two touchdowns as a receiver.
• Luke Wysong has put together a 97-yard season so far. He’s caught five passes on six targets.
• Brandon Phelps has racked up 76 reciving yards (25.3 ypg) and one touchdown this season.
• Chase Kennedy has 2.0 sacks to lead the team, and also has 2.0 TFL and five tackles.
• Dalton Johnson, Arizona’s tackle leader, has 13 tackles this year.
• Genesis Smith has picked off a team-leading one pass. He also has 12 tackles and four passes defended to his name.