The No. 2 Indiana Hoosiers (11-0) hit the road for a Big Ten battle against the Purdue Boilermakers (2-9) on Friday, November 28, 2025 at Ross-Ade Stadium.

The Boilermakers are expected to lose by at least two touchdowns (currently +28.5) versus the Hoosiers (with an over/under of 54.5 points).

Below you’ll find our preview for this this contest between the Hoosiers and the Boilermakers, and find all of our betting picks here, too!

Indiana vs. Purdue betting lines

• Spread favorite: Hoosiers (-28.5)
• Moneyline: Hoosiers (-7143), Boilermakers (+1875)
• Total: 54.5 points
• TV Channel: NBC (KPVI Idaho Falls-Pocatello, ID)
• Live Stream: Fubo

Indiana vs. Purdue betting info and stats

Indiana, through 11 games with a spread so far this season, is 6-5-0 against the spread. Indiana has covered the spread two times when the favorite by at least 28.5 points (a 2-1 ATS record). Indiana has been the moneyline favorite for nine games this season, and it has put up a 9-0 record in those matchups. Purdue has an against-the-spread record of 5-6-0 so far this season. In the one game Purdue has been an underdog by at least 28.5 points this season, it has covered the spread. This is the ninth time this year Purdue is the moneyline underdog, and have lost each such contest.

Indiana vs. Purdue recent stats and trends

Indiana Hoosiers

• Indiana is 1-2 against the spread and 3-0 overall in its past three games.
• The final combined score of the past three Indiana games has gone over the set total two times.
• The last three Indiana games averaged 48.2 total points, 6.3 fewer points than this matchup’s over/under.

Purdue Boilermakers

• Purdue is 2-1 against the spread and 3-0 overall over its last three contests.
• Purdue and its opponents have hit the over in one of those games.
• The past three Purdue games averaged 5.0 fewer points (49.5) than this matchup’s point total.

Indiana vs. Purdue key players

Indiana Hoosiers

• Fernando Mendoza has recorded 2,641 yards (240.1 ypg) on 203-of-278 passing with 30 touchdowns compared to five interceptions this season. In addition, he’s added 216 rushing yards (19.6 ypg) on 62 carries while scoring five touchdowns on the ground.
• Roman Hemby has racked up 714 yards on 151 carries while finding paydirt five times as a runner. He’s also caught 13 passes for 153 yards (15.3 per game).
• Kaelon Black has been handed the ball 114 times this year and racked up 663 yards (60.3 per game) with five touchdowns.
• Omar Cooper Jr. has hauled in 56 receptions for 764 yards (69.5 yards per game) to lead the team so far this season. He’s found the end zone 10 times as a receiver.
• Elijah Sarratt has put together a 585-yard season so far with 10 touchdowns, reeling in 44 passes on 64 targets.
• E.J. Williams has compiled 33 grabs for 404 yards, an average of 36.7 yards per game. He’s scored five times as a receiver this season.
• Rolijah Hardy leads the team with 7.0 sacks. He’s also the team’s tackle leader, and has recorded 9.0 TFL and 56 tackles.
• Louis Moore has a team-leading four interceptions to go along with 54 tackles, 2.0 TFL, and four passes defended.

Purdue Boilermakers

• Ryan Browne has racked up 1,915 yards on 59.8% passing while tossing nine touchdown passes with nine interceptions this season. He’s also rushed for 203 yards with four scores.
• Devin Mockobee has rushed 125 times for 521 yards, with four touchdowns. He’s also tacked on 18 catches for 215 yards and one touchdown.
• Antonio Harris has piled up 274 yards (on 54 attempts) with two touchdowns.
• Michael Jackson III has racked up 504 receiving yards on 57 receptions to pace his team so far this season while scoring one touchdown as a receiver.
• Nitro Tuggle has racked up 425 receiving yards (38.6 yards per game) and four touchdowns on 29 receptions.
• EJ Horton’s 41 targets have resulted in 23 receptions for 248 yards and one touchdown.
• Mani Powell paces the team with 5.0 sacks. He’s also the team’s tackle leader, and has amassed 7.0 TFL and 82 tackles.
• Hudauri Hines has a team-leading one interception to go along with 24 tackles and one pass defended.