Big Ten opponents meet when the No. 2 Indiana Hoosiers (9-0) and the Penn State Nittany Lions (3-5) square off on Saturday, November 8, 2025 at West Shore Home Field at Beaver Stadium.
The Nittany Lions are expected to lose by at least two TDs (currently +14) against the Hoosiers (with an over/under of 50.5 points).
Read on for our preview for this this game between the Hoosiers and the Nittany Lions, and discover all of our expert picks here, too!
Betting Odds
Bet $20, Payout $38.18
Indiana -14 vs. Penn State
Indiana vs. Penn State betting lines
- Spread favorite: Hoosiers (-14)
- Moneyline: Hoosiers (-662), Nittany Lions (+479)
- Total: 50.5 points
- TV Channel: FOX 4K
- Live Stream: Fubo
Indiana vs. Penn State betting info and stats
- Indiana, through nine games with a spread this season, is 6-3-0 against the spread. Indiana is 4-2 ATS when the favorite by at least 14 points. Indiana is 7-0 in the seven games this season it has been the moneyline favorite. Penn State has won just one game against the spread so far this season (1-7-0). Penn State has not covered the spread in games it was an underdog by at least 14 points (0-1). This will be the third game this year Penn State is an underdog on the moneyline, after losing the previous two such games.
Indiana vs. Penn State recent stats and trends
Indiana Hoosiers
- Indiana is 2-1 against the spread and 3-0 overall in its last three contests.
- In each of those games, the final combined score has exceeded the set total.
- The past three Indiana games averaged 0.5 more points (51.0) than this matchup’s over/under.
Penn State Nittany Lions
- Penn State is 1-2 against the spread and 3-0 overall during its last three games.
- Two times in those three games, the final combined score has gone over the set total.
- The past three Penn State games averaged 6.0 fewer points (44.5) than this matchup’s point total.
Indiana vs. Penn State key players
Indiana Hoosiers
- Fernando Mendoza has thrown for 2,124 yards (236.0 ypg) to lead Indiana, completing 72.3% of his passes and collecting 25 touchdown passes compared to four interceptions this season. He’s also contributed in the ground game with 220 rushing yards on 50 carries with four rushing touchdowns.
- The team’s top rusher, Kaelon Black, has carried the ball 96 times for 619 yards (68.8 per game), scoring four times.
- Roman Hemby has been handed the ball 125 times this year and racked up 601 yards (66.8 per game) with five touchdowns. He’s also contributed in the passing game with 11 grabs for 144 yards
- Omar Cooper Jr.’s team-leading 693 yards as a receiver have come on 47 receptions (out of 58 targets) with eight touchdowns.
- Elijah Sarratt has put up a 585-yard season so far with 10 touchdowns, hauling in 44 passes on 64 targets.
- E.J. Williams has a total of 336 receiving yards so far this year, grabbing 26 throws and scoring five touchdowns.
- Isaiah Jones has 5.0 sacks to lead the team, and also has 9.0 TFL, 41 tackles, and one interception.
- Louis Moore has been all over the field, leading the team in both tackles and interceptions. He has 50 tackles, 2.0 TFL, and four interceptions so far.
Penn State Nittany Lions
- Drew Allar leads Penn State with 1,100 yards on 103-of-159 passing with eight touchdowns compared to three interceptions this season. He has chipped in with 172 rushing yards (28.7 ypg) on 36 carries while scoring one touchdown on the ground.
- Kaytron Allen has run for 688 yards on 119 carries so far this year while scoring 10 times on the ground.
- Nicholas Singleton has piled up 82 carries and totaled 292 yards with seven touchdowns while also gaining 123 yards through the air .
- Devonte Ross leads his squad with 281 receiving yards on 23 receptions with three touchdowns.
- Kyron Ware-Hudson has caught 20 passes and compiled 236 receiving yards (29.5 per game) with two touchdowns.
- Trebor Pena has racked up 232 reciving yards (29.0 ypg) and one touchdown this season.
- Tony Rojas has 2.0 sacks to pace the team, and also has 4.0 TFL and 24 tackles.
- Amare Campbell, Penn State’s top tackler, has 58 tackles, 5.0 TFL, and two sacks this year.
- Zane Durant has a team-leading one interception to go along with 20 tackles, 2.0 TFL, two sacks, and one pass defended.
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