The No. 11 Indiana Hoosiers (4-0) and the Iowa Hawkeyes (3-1) play on Saturday, September 27, 2025 at Kinnick Stadium in a battle of Big Ten foes.

The Hawkeyes are expected to lose (currently +8.5) versus the Hoosiers (with an over/under of 47.5 points).

Below you can find our preview for this this contest between the Hoosiers and the Hawkeyes, and discover all of our predictions here, too!

Indiana vs. Iowa betting lines

• Spread favorite: Hoosiers (-8.5)
• Moneyline: Hoosiers (-331), Hawkeyes (+264)
• Total: 47.5 points

Indiana vs. Iowa betting info and stats

Indiana has a 3-1-0 record against the spread this season. Indiana has covered the spread in two games when the favorite by at least 8.5 points (a 2-1 ATS record). Indiana has been named as moneyline favorites three times this season, and has put together a 3-0 record in those matchups. Iowa has a pair of wins against the spread so far this season (2-1-1). Iowa has played as an underdog on the moneyline in one game so far this season, and failed to pick up the victory.

Indiana vs. Iowa recent stats and trends

Indiana Hoosiers

Iowa Hawkeyes

Indiana vs. Iowa key players

Indiana Hoosiers

• Fernando Mendoza has thrown for 975 yards (243.8 ypg) to lead Indiana, completing 76.8% of his passes and recording 14 touchdown passes this season. He’s also figured in the ground game with 76 rushing yards on 22 carries with two rushing touchdowns.
• The team’s top rusher, Kaelon Black, has carried the ball 44 times for 306 yards (76.5 per game), scoring two times.
• This season, Roman Hemby has carried the ball 50 times for 265 yards (66.3 per game), while also racking up 71 yards through the air.
• Omar Cooper Jr.’s team-high 377 yards as a receiver have come on 19 catches (out of 22 targets) with five touchdowns.
• Elijah Sarratt has hauled in 24 receptions totaling 256 yards, finding the end zone five times as a receiver so far this campaign.
• E.J. Williams has a total of 116 receiving yards so far this year, grabbing 13 passes and scoring two touchdowns.
• Tyrique Tucker has collected 3.0 sacks to pace the team, while also picking up 4.0 TFL and 11 tackles.
• Indiana’s leading tackler, Louis Moore, has 17 tackles, 2.0 TFL, and two interceptions this year.
• Amare Ferrell has picked off a team-leading two passes. He also has seven tackles, 1.0 TFL, and two passes defended to his name.

Iowa Hawkeyes

• Mark Gronowski has recored 492 passing yards, or 123.0 per game, so far this season. He has completed 60.5% of his passes and has recorded three touchdowns with one interception. He’s also chipped in on the ground with 35.8 rushing yards per game while scoring as a runner six times.
• The team’s top rusher, Jaziun Patterson, has carried the ball 34 times for 198 yards (49.5 per game).
• Xavier Williams has been given 26 carries and totaled 186 yards with one touchdown.
• Sam Phillips has hauled in 115 receiving yards on five receptions to pace his squad so far this season.
• Jacob Gill has totaled 91 receiving yards (22.8 yards per game) on eight receptions.
• Dayton Howard’s three receptions (on three targets) have netted him 53 yards (26.5 ypg).
• Max Llewellyn has collected 4.0 sacks to pace the team, while also picking up 5.0 TFL and nine tackles.
• Jaden Harrell, Iowa’s top tackler, has 29 tackles, 1.0 TFL, and one sack this year.
• Jaxon Rexroth leads the team with one interception, while also recording seven tackles, 1.0 TFL, and one pass defended.