Astros vs. Diamondbacks Betting Lines, Odds, & Player Matchups July 22, 2025

Data Skrive
Data Skrive

Eugenio Suarez leads the Arizona Diamondbacks (50-50) into a matchup against the Houston Astros (57-42) after he homered twice in a 5-3 win over the Cardinals. The Astros are favored on the moneyline (-125) against the Diamondbacks (+105) in this outing, which starts at 9:40 p.m. ET on Tuesday. Houston’s Framber Valdez and Arizona’s Eduardo Rodriguez will take the mound first.

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Moneyline

Astros to win vs Diamondbacks -125

Bet $20, Payout $36.00

Astros vs. Diamondbacks betting lines

  • Favorite: Astros (-125)
  • Underdog: Diamondbacks (+105)
  • Over/under: 8.5

Astros betting info, hitting leaders, & pitching

Astros betting info

  • The Astros have won 39 of the 68 games they were listed as the moneyline favorite this season (57.4%).
  • When playing as moneyline favorites with odds of -125 or shorter, Houston has a 28-19 record (winning 59.6% of its games).
  • The Astros have a 55.6% chance to win this game based on the moneyline’s implied probability.
  • Houston has had an over/under set by oddsmakers 99 times, and have combined with opponents to go over the total in 43 of those games (43-52-4).
  • The Astros have collected a 50-49-0 record ATS this season.

Astros hitting info

  • Jose Altuve leads the Astros with 53 runs batted in.
  • Altuve ranks 38th in homers and 51st in RBI among all batters in MLB action.
  • Altuve heads into this matchup on a two-game hitting streak. In his last five games he is batting .381 with two doubles, a home run, two walks and two RBIs.
  • Yainer Diaz has 11 doubles, a triple, 13 home runs and 14 walks while hitting .239.
  • Among all MLB hitters, Diaz ranks 76th in home runs and 114th in RBI.
  • Cam Smith is batting .270 with 17 doubles, two triples, seven home runs and 27 walks.
  • Smith enters this game on a two-game hitting streak. During his last five outings he is batting .091 with a double, two walks and three RBIs.
  • Christian Walker has 12 doubles, a triple, 13 home runs and 25 walks while hitting .227.
  • Walker has safely hit in two games in a row. In his last five games he is batting .150 with a home run, two walks and four RBIs.

Astros pitching rankings

  • The 9.8 strikeouts per nine innings put together by the Astros pitching staff leads the majors.
  • Houston has a 3.64 team ERA that ranks fifth across all MLB pitching staffs.
  • Astros pitchers combine for the No. 2 WHIP in the majors (1.170).
  • Astros pitchers combine to give up 111 total home runs at a clip of 1.1 per game (17th-fewest in baseball).
  • In its 11-3 win last time out, Houston struck out 13 Mariners batters while allowing 10 hits.

Diamondbacks betting info, hitting leaders, & pitching

Diamondbacks betting info

  • The Diamondbacks have won 17, or 48.6%, of the 35 games they’ve played as underdogs this season.
  • Arizona has entered 23 games this season as the underdog by +105 or more and is 14-9 in those contests.
  • Oddsmakers have implied with the moneyline set for this matchup that the Diamondbacks have a 48.8% chance to win.
  • Games involving Arizona have gone over the total set by bookmakers in 52 of 99 chances this season.
  • The Diamondbacks are 50-49-0 ATS in their 99 games with a spread this season.

Diamondbacks hitting info

  • Geraldo Perdomo has been key for Arizona with 10 home runs, 72 RBI and a batting average of .272 this season.
  • Among all batters in the majors, Perdomo is 131st in homers and ninth in RBI.
  • Perdomo has hit safely in three games in a row. In his last five games he is batting .333 with a triple, three walks and seven RBIs.
  • Suarez is batting .257 this season with a team-high 35 home runs and 85 RBI.
  • Suarez is third in home runs and first in RBI among all hitters in the big leagues.
  • Suarez has hit safely in five games in a row. In his last five games he is batting .500 with a double, six home runs, four walks and 10 RBIs.
  • Josh Naylor’s batting average of .292 leads all Arizona hitters this season.
  • Corbin Carroll has 84 hits and an OBP of .328 to go with a slugging percentage of .564 this season.
  • Carroll takes a two-game hitting streak into this game. During his last five outings he is batting .261 with two doubles, three triples, a walk and an RBI.

Diamondbacks pitching rankings

  • The Diamondbacks average the 14th-most strikeouts per nine innings (8.5) in the majors this season.
  • Arizona has the 25th-ranked ERA (4.58) in the majors this season.
  • The Diamondbacks rank 23rd in MLB with a combined 1.330 WHIP this season.
  • With 128 homers allowed, the Diamondbacks rank 24th in the league at preventing long balls.
  • Arizona pitchers struck out nine Cardinals batters while allowing seven hits in a 5-3 win last time out.
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