The outings in a Week 6 college football lineup that shouldn’t be missed include the Sam Houston Bearkats squaring off against the New Mexico State Aggies at Aggie Memorial Stadium.
Check out our odds breakdown for college football’s Week 6.
Keep reading for our previews for this season, and discover all of our predictions here, too!
Week 6’s Closest Projected College Football Games (by Spread)
Sam Houston (0-5) at New Mexico State (3-2)
- Game Time: 9 p.m. ET | Thursday, October 2, 2025
- New Mexico St Last Game: 37-10 W vs Sam Houston
- Sam Houston Last Game: 37-10 L vs New Mexico State
Sam Houston -1.5 vs. New Mexico State
New Mexico (3-2) at San Jose State (2-3)
- Game Time: 10 p.m. ET | Friday, October 3, 2025
- SJSU Last Game: 35-28 W vs New Mexico
- UNM Last Game: 35-28 L vs San Jose State
San Jose State -1.5 vs. New Mexico
No. 14 Iowa State (5-1) at Cincinnati (4-1)
- Game Time: 12 p.m. ET | Saturday, October 4, 2025
- Cincy Last Game: 38-30 W vs Iowa State
- Iowa St Last Game: 38-30 L vs Cincinnati
Cincinnati -1.5 vs. Iowa State
Oregon State (0-6) at Appalachian State (3-2)
- Game Time: 3:30 p.m. ET | Saturday, October 4, 2025
- App State Last Game: 27-23 W vs Oregon State
- Oregon St Last Game: 27-23 L vs Appalachian State
Appalachian State -1.5 vs. Oregon State
Western Kentucky (5-1) at Delaware (3-2)
- Game Time: 7 p.m. ET | Friday, October 3, 2025
- Delaware Last Game: 27-24 L vs Western Kentucky
- WKU Last Game: 27-24 W vs Delaware
Delaware -2.5 vs. Western Kentucky
South Alabama (1-4) at Troy (2-2)
- Game Time: 7 p.m. ET | Saturday, October 4, 2025
- Troy Last Game: 21-17 W vs Buffalo
- So. Alabama Last Game: 36-22 L vs North Texas
South Alabama -2.5 vs. Troy
Duke (3-2) at California (4-1)
- Game Time: 10:30 p.m. ET | Saturday, October 4, 2025
- Cal Last Game: 28-24 W vs Boston College
- Duke Last Game: 38-3 W vs Syracuse
Duke -3 vs. California
Kansas (3-2) at UCF (3-1)
- Game Time: 7:30 p.m. ET | Saturday, October 4, 2025
- UCF Last Game: 34-20 L vs Kansas State
- Kansas Last Game: 37-34 L vs Cincinnati
Kansas -3.5 vs. UCF
No. 3 Miami (FL) (4-0) at No. 18 Florida State (3-1)
- Game Time: 7:30 p.m. ET | Saturday, October 4, 2025
- FSU Last Game: 46-38 L vs Virginia
- Miami Last Game: 26-7 W vs Florida
Miami (FL) -3.5 vs. Florida State
Florida Atlantic (1-3) at Rice (3-2)
- Game Time: 7 p.m. ET | Saturday, October 4, 2025
- Rice Last Game: 21-13 L vs Navy
- FAU Last Game: 55-26 L vs Memphis
Rice -4 vs. Florida Atlantic
BetDecider Team
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