College Football Week 5 Best Games

Data Skrive
Data Skrive

In a Week 5 college football slate that has plenty of exciting matchups, the San Diego State Aztecs versus the Northern Illinois Huskies is a game to catch.

To pick up an edge prior to Week 5 in college football, read our odds breakdown below.

Below you’ll find our betting primers for this season, and uncover all of our expert picks here, too!

Week 5’s Closest Projected College Football Games (by Spread)

San Diego State (3-1) at Northern Illinois (1-3)

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  • Game Time: 3:30 p.m. ET | Saturday, September 27, 2025
  • NIU Last Game: 6-3 L vs San Diego State
  • SDSU Last Game: 6-3 W vs Northern Illinois
Odds to Cover

San Diego State -1.5 vs. Northern Illinois

Bet $20, Payout $38.18

Arkansas State (1-4) at Louisiana-Monroe (3-1)

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  • Game Time: 3 p.m. ET | Saturday, September 27, 2025
  • ULM Last Game: 28-16 W vs Arkansas State
  • Arkansas St Last Game: 28-16 L vs Louisiana-Monroe
Spread

Louisiana-Monroe -1.5 vs. Arkansas State

Bet $20, Payout $38.18

Marshall (2-2) at Louisiana (1-3)

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  • Game Time: 8 p.m. ET | Saturday, September 27, 2025
  • Louisiana Last Game: 34-31 L vs Eastern Michigan
  • Marshall Last Game: 42-28 W vs Middle Tennessee
Spread

Marshall -2.5 vs. Louisiana

Bet $20, Payout $38.52

No. 17 Alabama (2-1) at No. 5 Georgia (3-0)

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  • Game Time: 7:30 p.m. ET | Saturday, September 27, 2025
  • UGA Last Game: 44-41 W vs Tennessee
  • Alabama Last Game: 38-14 W vs Wisconsin
Spread

Georgia -2.5 vs. Alabama

Bet $20, Payout $38.35

No. 4 LSU (4-1) at No. 13 Ole Miss (5-0)

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  • Game Time: 3:30 p.m. ET | Saturday, September 27, 2025
  • Ole Miss Last Game: 24-19 W vs LSU
  • LSU Last Game: 24-19 L vs Ole Miss
To Cover the Spread

Ole Miss -2.5 vs. LSU

Bet $20, Payout $38.69

TCU (3-1) at Arizona State (4-1)

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  • Game Time: 9 p.m. ET | Friday, September 26, 2025
  • ASU Last Game: 27-24 W vs TCU
  • TCU Last Game: 27-24 L vs Arizona State
To Cover the Spread

Arizona State -3 vs. TCU

Bet $20, Payout $39.05

UConn (3-2) at Buffalo (2-3)

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  • Game Time: 3:30 p.m. ET | Saturday, September 27, 2025
  • Buffalo Last Game: 20-17 L vs UConn
  • UConn Last Game: 20-17 W vs Buffalo
To Cover the Spread

UConn -3 vs. Buffalo

Bet $20, Payout $38.18

Eastern Michigan (1-4) at Central Michigan (3-2)

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  • Game Time: 1 p.m. ET | Saturday, September 27, 2025
  • CMU Last Game: 24-13 W vs Eastern Michigan
  • EMU Last Game: 24-13 L vs Central Michigan
Spread

Central Michigan -3 vs. Eastern Michigan

Bet $20, Payout $37.39

San Jose State (1-2) at Stanford (1-3)

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  • Game Time: 7:30 p.m. ET | Saturday, September 27, 2025
  • Stanford Last Game: 48-20 L vs Virginia
  • SJSU Last Game: 31-28 W vs Idaho
To Cover the Spread

Stanford -3 vs. San Jose State

Bet $20, Payout $37.86

Louisiana Tech (3-1) at UTEP (1-3)

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  • Game Time: 9 p.m. ET | Saturday, September 27, 2025
  • UTEP Last Game: 31-25 L vs Louisiana-Monroe
  • La. Tech Last Game: 30-20 W vs Southern Miss
Betting Odds

Louisiana Tech -3.5 vs. UTEP

Bet $20, Payout $38.02
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Ryan Knuppel

Knup Solutions [molongui_author_name]

About Ryan Knuppel

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Betting Guide

How Money Line Works?

Moneyline betting is by far the easiest way to place a sports wager. There are no point spreads to parse, no garbage-time free throws to ruin your betting day, and no last-minute meaningless touchdowns to take you from a winner to a loser.

How to Bet Odds

When we, as sports fans, learned our multiplication tables, we aced the number 7. Seven, 14, 21, 28, 35, 42 were easy because we all watched football on the weekends. Multiplication by sevens, then add a three, a six after a missed PAT.

How to Bet on NFL Games

Baseball is America’s pastime, but football is America’s crazed passion, with its weekly schedule of games, millions of television viewers across the country and the world, and the billion-dollar stadiums that serve as Sunday cathedrals in 32 American cities.

What is the Spread?

If you are a golfer or have ever played on a bowling team, think of a point spread like a handicap. It is a way for two teams of differing abilities to play each other on equal footing.  The better team, and the favorite in the game, gives a certain amount …