Reds vs. Pirates Betting Lines, Odds, & Player Matchups September 24, 2025

Data Skrive
Data Skrive

The Cincinnati Reds (80-76) host the Pittsburgh Pirates (67-89) on Wednesday at Great American Ball Park, starting at 6:40 p.m. ET. The Reds are favored on the moneyline (-120), while the Pirates are -100 underdogs, even though they are favored against the spread (1.5) with +171 odds. Hunter Greene starts for Cincinnati while Pittsburgh will counter with Paul Skenes.

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Odds to Win

Reds to win vs Pirates -120

Bet $20, Payout $36.67

Reds vs. Pirates betting lines

  • Favorite: Reds (-120)
  • Underdog: Pirates (-100)
  • Over/under: 7

Reds betting info, hitting leaders, & pitching

Reds betting info

  • The Reds have been the moneyline favorite 69 total times this season. They’ve finished 37-32 in those games.
  • Cincinnati has a 30-25 record (winning 54.5% of its games) when playing as moneyline favorites of -120 or shorter.
  • Based on this game’s moneyline, the Reds’ implied win probability is 54.5%.
  • Cincinnati has played in 153 games with set over/under, and have combined with opponents to go over the total 58 times (58-87-8).
  • The Reds have a 79-74-0 record ATS this season (covering 51.6% of the time).

Reds hitting info

  • Elly De La Cruz has a team-best 83 runs batted in.
  • Among all hitters in MLB action, De La Cruz’s home run total ranks 76th and his RBI tally ranks 33rd.
  • De La Cruz takes a three-game hitting streak into this game. In his last five games he is hitting .214 with a double, a home run, four walks and an RBI.
  • TJ Friedl is hitting .257 with 20 doubles, two triples, 13 home runs and 76 walks.
  • Friedl ranks 156th in home runs and 168th in RBI this season.
  • Spencer Steer has put up a team-best 21 home runs.
  • Austin Hays has 16 doubles, five triples, 15 home runs and 29 walks while batting .266.

Reds pitching rankings

  • The 8.6 strikeouts per nine innings compiled by the Reds pitching staff ranks 12th in the majors.
  • Cincinnati has a 3.92 team ERA that ranks 14th across all MLB pitching staffs.
  • Reds pitchers combine for the No. 9 WHIP in MLB (1.234).
  • The Reds surrender the 18th-fewest home runs in baseball (187 total, 1.2 per game).
  • Cincinnati struck out six Cubs batters while allowing six hits in a 1-0 win in its last game.

Pirates betting info, hitting leaders, & pitching

Pirates betting info

  • This season, the Pirates have been the underdog 108 times and won 44, or 40.7%, of those games.
  • Pittsburgh is 37-58 this season when entering a game as the underdog by -100 or more on the moneyline.
  • The oddsmakers’ moneyline implies a 50% chance of a victory for the Pirates.
  • So far this season, Pittsburgh and its opponents have hit the over in 63 of its 155 games with a total.
  • The Pirates have an ATS record of 83-72-0 in 155 games with a spread this season.

Pirates hitting info

  • Bryan Reynolds leads Pittsburgh in runs batted in with 73 while batting .244, which is also best on the team.
  • Among all hitters in MLB, Reynolds’ home run total is 122nd, and his RBI total is 71st.
  • Reynolds has hit safely in three straight games. In his last five games he is hitting .313 with a double, a home run, four walks and two RBIs.
  • Andrew McCutchen has 111 hits and an OBP of .336 to go with a slugging percentage of .372 this season.
  • McCutchen is 156th in homers and 133rd in RBI among all major league hitters this season.
  • Oneil Cruz leads Pittsburgh in home runs with 19. He’s driven in 59 runs and is slugging .379.
  • Cruz has safely hit in two games in a row. In his last five games he is hitting .176 with a triple, a walk and three RBIs.
  • Spencer Horwitz is batting .257 with an OBP of .338 and a slugging percentage of .402 this season.

Pirates pitching rankings

  • The Pirates have an 8.2 K/9 this season as a pitching staff, which ranks 21st in the big leagues.
  • Pittsburgh has the eighth-best ERA (3.83) in the majors this season.
  • The Pirates have a combined 1.221 WHIP as a pitching staff, fifth-lowest in MLB.
  • The Pirates have allowed the third-fewest home runs this season at just 147, or 0.9 per game.
  • Pittsburgh pitchers struck out nine Athletics batters while allowing eight hits in an 11-0 win last time out.
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Betting Guide

How Money Line Works?

Moneyline betting is by far the easiest way to place a sports wager. There are no point spreads to parse, no garbage-time free throws to ruin your betting day, and no last-minute meaningless touchdowns to take you from a winner to a loser.

How to Bet Odds

When we, as sports fans, learned our multiplication tables, we aced the number 7. Seven, 14, 21, 28, 35, 42 were easy because we all watched football on the weekends. Multiplication by sevens, then add a three, a six after a missed PAT.

How to Bet on NFL Games

Baseball is America’s pastime, but football is America’s crazed passion, with its weekly schedule of games, millions of television viewers across the country and the world, and the billion-dollar stadiums that serve as Sunday cathedrals in 32 American cities.

What is the Spread?

If you are a golfer or have ever played on a bowling team, think of a point spread like a handicap. It is a way for two teams of differing abilities to play each other on equal footing.  The better team, and the favorite in the game, gives a certain amount …