Cubs vs. Pirates Betting Lines, Odds, & Player Matchups September 17, 2025

Data Skrive
Data Skrive

Nico Hoerner brings a 10-game hitting streak into the Chicago Cubs’ (86-64) matchup against the Pittsburgh Pirates (65-86). The Cubs are the moneyline favorite (-154) in this outing against the Pirates (+129), which starts at 12:35 p.m. ET on Wednesday at PNC Park. Chicago’s Matthew Boyd starts against Pittsburgh’s Johan Oviedo.

Check out all the Latest Baseball Betting Previews!

Money Line

Cubs to win vs Pirates -154

Bet $20, Payout $32.99

Cubs vs. Pirates betting lines

  • Favorite: Cubs (-154)
  • Underdog: Pirates (+129)
  • Over/under: 8

Cubs betting info, hitting leaders, & pitching

Cubs betting info

  • The Cubs have been favored on the moneyline 109 total times this season. They’ve gone 69-40 in those games.
  • When playing as moneyline favorites with odds of -154 or shorter, Chicago has gone 39-16 (70.9%).
  • The implied moneyline probablility in this matchup gives the Cubs a 60.6% chance to win.
  • In the 150 games in which bookmakers have set an over/under for Chicago, it has combined with opponents to go over the total 68 times (68-73-9).
  • The Cubs have collected a 69-81-0 record ATS this season.

Cubs hitting info

  • Hoerner has accumulated a team-high batting average of .299.
  • In MLB play, Hoerner ranks 269th in home runs and 114th in RBI.
  • Hoerner brings a 10-game hitting streak into this game. In his last 10 outings he is batting .436 with five doubles, a triple, a home run, five walks and five RBIs.
  • Pete Crow-Armstrong has hit 29 home runs to pace his team.
  • Crow-Armstrong ranks 21st in homers and 22nd in RBI among MLB hitters this season.
  • Ian Happ has 28 doubles, 22 home runs and 82 walks while batting .242.
  • Happ heads into this matchup on a two-game hitting streak. In his last five games he is hitting .350 with a double, two home runs, three walks and three RBIs.
  • Seiya Suzuki’s 91 runs batted in pace his team.
  • Suzuki takes a six-game hitting streak into this game. During his last 10 outings he is batting .211 with a double, six walks and four RBIs.

Cubs pitching rankings

  • The 7.8 strikeouts per nine innings compiled by the Cubs pitching staff ranks 27th in the majors.
  • Chicago has the seventh-ranked team ERA across all MLB pitching staffs (3.84).
  • The Cubs have the second-lowest WHIP in baseball (1.191).
  • Cubs pitchers combine to give up 184 total home runs at a clip of 1.2 per game (22nd-fewest in MLB).
  • In its 4-0 win last time out, Chicago struck out six Pirates batters while allowing three hits.

Pirates betting info, hitting leaders, & pitching

Pirates betting info

  • The Pirates have been underdogs in 105 games this season and won 43 (41%) of those contests.
  • Pittsburgh is 18-32 this season when entering a game as the underdog by +129 or more on the moneyline.
  • The moneyline for this contest implies a 43.7% chance of a victory for the Pirates.
  • Pittsburgh’s games have gone over the total in 61 of its 150 chances.
  • In 150 games with a spread this season, the Pirates are 80-70-0 ATS.

Pirates hitting info

  • Bryan Reynolds is batting .243 with 71 RBI, both of which are best among Pittsburgh hitters this season.
  • Among all hitters in the majors, Reynolds’ home run total is 129th, and his RBI total is 69th.
  • Andrew McCutchen is batting .239 with an OBP of .334 and a slugging percentage of .376 this season.
  • McCutchen ranks 154th in homers and 130th in RBI among all MLB hitters this year.
  • Oneil Cruz is slugging .382 this season, with a team-high 19 home runs. He’s also collected 56 RBI.
  • Spencer Horwitz is batting .260 with an OBP of .336 and a slugging percentage of .406 this season.
  • Horwitz heads into this matchup on a two-game hitting streak. During his last five outings he is batting .333 with a double, a home run, three walks and two RBIs.

Pirates pitching rankings

  • The Pirates average the 21st-most strikeouts per nine innings (8.2) in the majors this season.
  • Pittsburgh pitchers have a combined ERA of 3.87 ERA this year, which ranks 11th in MLB.
  • The Pirates have a combined WHIP of just 1.224 as a pitching staff, which is the sixth-best in baseball this season.
  • The Pirates have allowed the third-fewest home runs this season at just 142, or 0.9 per game.
  • Last time out, Pittsburgh fell to the Cubs 4-0. Its pitchers compiled six strikeouts and nine hits allowed.
Author Profile
BetDecider Team

The BetDecider team brings you the most current sports betting content, with expert insights and tips. Our aim is that you can make an informed betting decision, including best odds and exclusive sportsbook offers, to maximize your betting experience.

Ryan Knuppel

Knup Solutions [molongui_author_name]

About Ryan Knuppel

Ryan has been one of the leading sports business & iGaming professionals for over 15 years. He started as a freelance writer and now operates one of the top sports content agencies around, Knup Solutions. He has literally written 10,000 plus sports and betting related articles across the web.

 

Sports Network:

sports20.com, usawager.com, knupsports.com, baseballspotlight.com, basketballarticles.com, betdecider.com, njsportsbookreview.com, dunkelindex.com, sportspub.com, oddschoice.com

 

Betting Guide

How Money Line Works?

Moneyline betting is by far the easiest way to place a sports wager. There are no point spreads to parse, no garbage-time free throws to ruin your betting day, and no last-minute meaningless touchdowns to take you from a winner to a loser.

How to Bet Odds

When we, as sports fans, learned our multiplication tables, we aced the number 7. Seven, 14, 21, 28, 35, 42 were easy because we all watched football on the weekends. Multiplication by sevens, then add a three, a six after a missed PAT.

How to Bet on NFL Games

Baseball is America’s pastime, but football is America’s crazed passion, with its weekly schedule of games, millions of television viewers across the country and the world, and the billion-dollar stadiums that serve as Sunday cathedrals in 32 American cities.

What is the Spread?

If you are a golfer or have ever played on a bowling team, think of a point spread like a handicap. It is a way for two teams of differing abilities to play each other on equal footing.  The better team, and the favorite in the game, gives a certain amount …