The Arizona Wildcats (4-3) and the Colorado Buffaloes (3-5) play on Saturday, November 1, 2025 at Folsom Field in a battle of Big 12 opponents.

The Wildcats are the favorites (-4.5) in their matchup against the Buffaloes, with the over/under being 52.5 points. (In terms of the moneyline, the Wildcats are -185 and the Buffaloes are +153.)

Below you’ll find our preview for this this contest between the Wildcats and the Buffaloes, and discover all of our betting picks here, too!

Arizona vs. Colorado betting lines

• Spread favorite: Wildcats (-4.5)
• Moneyline: Wildcats (-185), Buffaloes (+153)
• Total: 52.5 points
• TV Channel: FOX Sports 1
• Live Stream: Fubo

Arizona vs. Colorado betting info and stats

Arizona, through six games with a spread this season, is 3-3-0 against the spread. Arizona is undefeated ATS (2-0) when the favorite by at least 4.5 points. In the three games favored on the moneyline, Arizona has put together a 2-1 record. Colorado is 4-4-0 against the spread in eight opportunities so far this season. When Colorado is an underdog by 4.5 points or more, it has covered the spread once (1-2 ATS). This is the seventh time this year Colorado is the moneyline underdog and has gone 1-5 in such contests.

Arizona vs. Colorado recent stats and trends

Arizona Wildcats

• Arizona has covered the spread once in its past three matchups while putting together a 1-2 record straight-up in those games.
• The final combined score of the past three Arizona games has exceeded the set total two times.
• The last three Arizona games averaged 50.2 total points, 2.3 fewer points than this matchup’s over/under.

Colorado Buffaloes

• Colorado is 1-2 against the spread in its past three games, and has a 1-2 straight-up record in those contests.
• Once in those three games, the final combined score surpassed the set total.
• The last three Colorado games averaged 52.7 total points, 0.2 more points than this matchup’s point total.

Arizona vs. Colorado key players

Arizona Wildcats

• Noah Fifita has compiled 1,829 yards (261.3 ypg) on 155-of-235 passing with 17 touchdowns compared to four interceptions this season. In addition, he’s added 78 rushing yards (11.1 ypg) on 58 carries while scoring three touchdowns on the ground.
• Ismail Mahdi has 445 rushing yards on 77 carries with one touchdown.
• Quincy Craig has been handed the ball 30 times this year and racked up 209 yards (34.8 per game) with one touchdown.
• Jayin Whatley’s leads his squad with 370 yards as a receiver. He’s racked up that yardage on 32 catches (out of 46 targets) and scored three touchdowns.
• Kris Hutson has grabbed 24 passes while averaging 63.6 yards per game and scoring two touchdowns.
• Luke Wysong has racked up 18 receptions for 249 yards, an average of 35.6 yards per game. He’s scored two times as a receiver this season.
• Riley Wilson has racked up 3.0 sacks to pace the team, while also recording 3.0 TFL and 15 tackles.
• Dalton Johnson is the team’s leading tackler this year. He’s collected 39 tackles, 1.0 TFL, one sack, and one interception.
• Jay’Vion Cole has a team-leading two interceptions to go along with 14 tackles, 2.0 TFL, one sack, and three passes defended.

Colorado Buffaloes

• Kaidon Salter has been a dual threat for Colorado this season. He has 1,193 passing yards (170.4 per game) while completing 62.2% of his passes. He’s tossed nine touchdown passes and five interceptions this season. On the ground, he’s compiled 267 yards (38.1 ypg) on 80 carries with five rushing touchdowns.
• Micah Welch is his team’s leading rusher with 68 carries for 281 yards, or 35.1 per game. He’s found the end zone two times on the ground, as well.
• Omarion Miller has collected 23 receptions this season and his team-high yardage total sits at 430 (61.4 yards per game). He’s been targeted 36 times and has four touchdowns.
• Joseph Williams has put together a 370-yard season so far with three touchdowns. He’s caught 24 passes on 36 targets.
• Sincere Brown’s 14 grabs (on 25 targets) have netted him 279 yards (34.9 ypg) and two touchdowns.
• Keaten Wade has 2.5 sacks to pace the team, and also has 4.0 TFL and 28 tackles.
• Jeremiah Brown, Colorado’s tackle leader, has 40 tackles, 5.0 TFL, and one sack this year.
• RJ Johnson has a team-high one interception to go along with six tackles and one pass defended.