SEC opponents meet when the No. 8 Oklahoma Sooners (8-2) and the No. 23 Missouri Tigers (7-3) play on Saturday, November 22, 2025 at Gaylord Family Oklahoma Memorial Stadium.
The Tigers are underdogs, but by less than a touchdown (+5.5), against the Sooners (with an over/under of 42.5 points).
Keep reading to check out our betting preview for this this game between the Sooners and the Tigers, and discover all of our expert picks here, too!
Spread
Bet $20, Payout $37.39
Oklahoma -5.5 vs. Missouri
Oklahoma vs. Missouri betting lines
- Spread favorite: Sooners (-5.5)
- Moneyline: Sooners (-242), Tigers (+196)
- Total: 42.5 points
- TV Channel: ESPN 4K
- Live Stream: Fubo
Oklahoma vs. Missouri betting info and stats
- Oklahoma has six wins against the spread in 10 opportunities so far this season (6-4-0). Oklahoma has covered the spread twice when the favorite by at least 5.5 points (a 2-2 ATS record). Oklahoma has been moneyline favorites five times this season, and sports a 4-1 record in those games. Missouri, through 10 games with a set spread so far this season, has gone 6-4-0 against the spread. When Missouri is an underdog of 5.5 points or more, it has have yet to cover the spread. Missouri has played a game as an underdog on the moneyline three times this season, losing each game.
Oklahoma vs. Missouri recent stats and trends
Oklahoma Sooners
- Oklahoma has covered the spread twice in its last three matchups while putting up a 2-1 record straight-up in those games.
- Oklahoma and its opponents have hit the over in two of those games.
- Oklahoma’s past three games have ended with an average of 51.2 points scored. That’s 8.7 more points than this contest’s over/under.
Missouri Tigers
- Missouri is 1-2 against the spread and 2-1 overall during its past three matchups.
- The final combined score of the last three Missouri games has gone over the set total two times.
- The past three Missouri games averaged 8.5 more points (51.0) than this matchup’s over/under.
Oklahoma vs. Missouri key players
Oklahoma Sooners
- John Mateer has 2,087 yards passing for Oklahoma, completing 63.9% of his passes and tossing eight touchdowns and seven interceptions this season. He’s also helped out on the ground with 329 rushing yards (36.6 ypg) on 104 carries with seven rushing touchdowns.
- Tory Blaylock has 404 rushing yards on 98 carries with four touchdowns.
- This season, Xavier Robinson has carried the ball 62 times for 366 yards (52.3 per game) and four touchdowns.
- Isaiah Sategna has hauled in 53 catches for 718 yards (71.8 yards per game) to lead the team so far this season. He’s found the end zone five times as a receiver.
- Deion Burks has hauled in 44 receptions totaling 454 yards, finding the end zone two times as a receiver so far this campaign.
- Jaren Kanak has a total of 433 receiving yards so far this year, hauling in 32 passes.
- R Mason Thomas has 6.5 sacks to pace the team, and also has 5.0 TFL and 21 tackles.
- Oklahoma’s leading tackler, Kip Lewis, has 43 tackles, 6.0 TFL, and three sacks this year.
- Eli Bowen has picked off a team-leading one pass. He also has 11 tackles and one pass defended to his name.
Missouri Tigers
- Beau Pribula has compiled 1,690 yards on 69.6% passing while tossing 11 touchdown passes with seven interceptions this season. He’s also run for 220 yards with five scores.
- Ahmad Hardy has run the ball 197 times for 1,346 yards, with 15 touchdowns.
- Jamal Roberts has run for 583 yards across 92 carries, scoring four touchdowns.
- Kevin Coleman Jr.’s 600 receiving yards (60.0 yards per game) lead the team. He has 56 receptions on 69 targets with one touchdown.
- Marquis Johnson has 28 receptions (on 45 targets) for a total of 345 yards (38.3 yards per game) and two touchdowns this year.
- Donovan Olugbode has racked up 318 reciving yards (31.8 ypg) and two touchdowns this season.
- Damon Wilson Jr. has collected 6.5 sacks to lead the team, while also recording 5.0 TFL, 15 tackles, and one interception.
- Josiah Trotter, Missouri’s top tackler, has 60 tackles, 8.0 TFL, and one sack this year.
- Toriano Pride Jr. has picked off a team-high two passes. He also has 19 tackles, 1.0 TFL, and two passes defended to his name.
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