Giants vs. Cardinals Betting Lines, Odds, & Player Matchups September 22, 2025

Data Skrive
Data Skrive

The St. Louis Cardinals (76-80) visit the San Francisco Giants (77-79) on Monday at 9:45 p.m. ET. The Cardinals are moneyline underdogs (+123) against the favored Giants (-148). San Francisco’s Justin Verlander and St. Louis’ Michael McGreevy pitch first for their squads in this matchup.

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Betting Odds

Giants to win vs Cardinals -148

Bet $20, Payout $33.51

Giants vs. Cardinals betting lines

  • Favorite: Giants (-148)
  • Underdog: Cardinals (+123)
  • Over/under: 7.5

Giants betting info, hitting leaders, & pitching

Giants betting info

  • The Giants have won 52.9% of the games this season when they were the moneyline favorite (46-41).
  • When it has played as moneyline favorites with odds of -148 or shorter, San Francisco has a record of 23-21 (52.3%).
  • Based on this game’s moneyline, the Giants have an implied win probability of 59.7%.
  • In the 156 games in which oddsmakers have set an over/under for San Francisco, it has combined with opponents to go over the total 72 times (72-74-10).
  • The Giants have a 73-83-0 record against the spread this season (covering 46.8% of the time).

Giants hitting info

  • Rafael Devers paces the Giants with 32 home runs and 105 runs batted in.
  • Among all hitters in MLB action, Devers’ home run total ranks 14th and his RBI tally ranks eighth.
  • Devers heads into this game on a two-game hitting streak. During his last five outings he is hitting .150 with a home run, three walks and three RBIs.
  • Jung Hoo Lee’s .261 batting average leads his team.
  • Lee ranks 243rd in homers and 149th in RBI among MLB hitters this season.
  • Willy Adames is hitting .226 with 21 doubles, two triples, 28 home runs and 79 walks.
  • Heliot Ramos has 24 doubles, a triple, 18 home runs and 51 walks while batting .256.

Giants pitching rankings

  • The Giants pitching staff is 15th in the majors with a collective 8.5 strikeouts per nine innings.
  • San Francisco has the ninth-ranked team ERA across all MLB pitching staffs (3.85).
  • Pitchers for the Giants combine for the 18th-ranked WHIP in MLB (1.303).
  • Giants pitchers combine to give up the fewest home runs in baseball (136 total, 0.9 per game).
  • San Francisco struck out six Dodgers batters while allowing seven hits in a 3-1 win in its last game.

Cardinals betting info, hitting leaders, & pitching

Cardinals betting info

  • The Cardinals have won 42, or 47.7%, of the 88 games they’ve played as underdogs this season.
  • St. Louis has a record of 12-21, a 36.4% win rate, when it’s set as an underdog of +123 or more by bookmakers this season.
  • Bookmakers have implied with the moneyline set for this matchup that the Cardinals have a 44.8% chance to win.
  • So far this season, St. Louis and its opponents have hit the over in 77 of its 155 games with a total.
  • The Cardinals are 79-76-0 ATS in their 155 games with a spread this season.

Cardinals hitting info

  • Alec Burleson leads St. Louis with a batting average of .289. He’s also hit 18 home runs with 66 RBI.
  • Among all batters in MLB, Burleson ranks 97th in homers and 94th in RBI.
  • Burleson has hit safely in six games in a row. In his last 10 outings he is batting .333 with three doubles, a triple, a home run, four walks and four RBIs.
  • Brendan Donovan is batting .282 with an OBP of .349 and a slugging percentage of .408 this season.
  • Among all major league hitters, Donovan is 207th in homers and 181st in RBI.
  • Donovan takes a six-game hitting streak into this matchup. During his last 10 games he is hitting .293 with three doubles, a home run, two walks and five RBIs.
  • Lars Nootbaar is slashing .236/.323/.366 this season for the Cardinals.
  • Ivan Herrera is batting .281 with an OBP of .369 and a slugging percentage of .455 this season.
  • Herrera has hit safely in three straight games. During his last five outings he is batting .222 with a home run, two walks and two RBIs.

Cardinals pitching rankings

  • The Cardinals average just 8.5 strikeouts per nine innings as a pitching staff, which ranks 29th in the big leagues.
  • St. Louis pitchers have a combined ERA of 4.23 ERA this year, which ranks 19th in MLB.
  • The Cardinals rank 22nd in MLB with a combined 1.318 WHIP this season.
  • The Cardinals have given up the fourth-fewest long balls so far this season with only 157 home runs allowed.
  • St. Louis earned a 5-1 win in its most recent game, striking out 10 Brewers batters while allowing seven hits.
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Betting Guide

How Money Line Works?

Moneyline betting is by far the easiest way to place a sports wager. There are no point spreads to parse, no garbage-time free throws to ruin your betting day, and no last-minute meaningless touchdowns to take you from a winner to a loser.

How to Bet Odds

When we, as sports fans, learned our multiplication tables, we aced the number 7. Seven, 14, 21, 28, 35, 42 were easy because we all watched football on the weekends. Multiplication by sevens, then add a three, a six after a missed PAT.

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What is the Spread?

If you are a golfer or have ever played on a bowling team, think of a point spread like a handicap. It is a way for two teams of differing abilities to play each other on equal footing.  The better team, and the favorite in the game, gives a certain amount …