The Pittsburgh Panthers (2-0) and the West Virginia Mountaineers (1-1) play at Mountaineer Field at Milan Puskar Stadium on Saturday, September 13, 2025.

The Panthers are significant favorites (-7.5) in their matchup against the Mountaineers, with the over/under being 55.5 points. (On the moneyline, the Panthers are -291 and the Mountaineers are +234.)

Keep reading to check out our betting primer for this this contest between the Panthers and the Mountaineers, and uncover all of our predictions here, too!

Pittsburgh vs. West Virginia betting lines

• Spread favorite: Panthers (-7.5)
• Moneyline: Panthers (-291), Mountaineers (+234)
• Total: 55.5 points
• TV Channel: ESPN
• Live Stream: Fubo

Pittsburgh vs. West Virginia betting info and stats

Pittsburgh has yet to lose a game against the spread so far this season (2-0-0). Pittsburgh is undefeated ATS (2-0) when the favorite by at least 7.5 points. Pittsburgh has won both games as a moneyline favorite this season. West Virginia has a single win against the spread this season (1-1-0). This is the first time on the year West Virginia is the moneyline underdog.

Pittsburgh vs. West Virginia key players

Pittsburgh Panthers

• Eli Holstein leads Pittsburgh with 519 yards (259.5 ypg) on 36-of-51 passing with eight touchdowns and two interceptions this season. He also has 77 rushing yards on 11 carries.
• Desmond Reid has 112 rushing yards on 18 carries, scoring one touchdown. He’s also added 71 yards (35.5 per game) on six catches.
• Raphael Williams’ 166 yards as a receiver pace the team. He’s been targeted 11 times and has registered seven receptions and two touchdowns.
• Cataurus Hicks has grabbed five passes while averaging 37.0 yards per game and scoring two touchdowns.
• Kyle Louis leads the team with 2.0 sacks, and also has 4.0 TFL and 11 tackles.
• Rasheem Biles is the team’s top-tackler this year. He’s amassed 14 tackles and 1.0 TFL.

West Virginia Mountaineers

• Nicco Marchiol has thrown for 402 yards on 32-of-46 passing with one touchdown and one interception this season. He has chipped on the ground, as well, with 65 yards and one rushing touchdown.
• Jahiem White is his team’s leading rusher with 24 carries for 133 yards, or 66.5 per game. He’s found paydirt three times on the ground, as well.
• Cam Vaughn has registered nine catches this season and his team-high yardage total sits at 169 (84.5 yards per game). He’s been targeted 13 times and has one touchdown.
• Jaden Bray has put up a 95-yard season so far. He’s caught seven passes on nine targets.
• Grayson Barnes has racked up 39 reciving yards (19.5 ypg) this season.
• Chase Wilson has collected 3.0 sacks to pace the team, while also picking up 4.0 TFL, 13 tackles, and one interception.
• Fred Perry is the team’s leading tackler this year. He’s amassed 14 tackles, 1.0 TFL, and one sack.
• Ben Cutter has picked off a team-leading one pass. He also has 10 tackles and one pass defended to his name.