The No. 1 Ohio State Buckeyes (1-0) face an FCS opponent, the Grambling Tigers (1-0), on Saturday, September 6, 2025 at Ohio Stadium.

The Buckeyes are very big favorites (currently -54.5) in their game against the Tigers, with the over/under being 62.5 points. (On the moneyline, the Buckeyes are and the Tigers are .)

Below you’ll find our preview for this this contest between the Buckeyes and the Tigers, and uncover all of our expert predictions here, too!

Ohio State vs. Grambling betting lines

• Spread favorite: Buckeyes (-54.5)
• Moneyline: Buckeyes (), Tigers ()
• Total: 62.5 points
• TV Channel: Big Ten Network
• Live Stream: Fubo

Ohio State vs. Grambling betting info and stats

• Ohio State was 10-6-0 against the spread last year.
• Out of 16 Ohio State games last year, eight went over the total.
• Grambling’s record against the spread last season was 4-6-0.
• There were four Grambling games (out of 10) that hit the over last year.

Ohio State vs. Grambling key players

Ohio State Buckeyes

• Will Howard had a passing stat line last year of 4,010 yards with a 73% completion rate (309-for-423), 35 touchdowns, 10 interceptions, and an average of 250.6 yards per game. His rushing stat line was 105 carries for 232 yards and seven TDs.
• Quinshon Judkins racked up 1,060 rushing yards (66.3 per game) and 14 touchdowns last year.
• TreVeyon Henderson posted 1,013 rushing yards on 144 carries and 10 touchdowns last season. He also made a mark receiving with 27 catches for 284 yards and one score.
• Jeremiah Smith hauled in 76 catches for 1,315 yards (82.2 per game) while being targeted 107 times. He also scored 15 touchdowns.
• Emeka Egbuka produced last year, grabbing 81 passes for 1,011 yards and 10 touchdowns. He collected 63.2 receiving yards per game.
• Carnell Tate hauled in 52 passes for 733 yards and four touchdowns, putting up 48.9 yards per game last year.
• J.T. Tuimoloau did his thing last season with a huge stat line of 12.5 sacks, 15.0 TFL and 54 tackles.
• Cody Simon went to work last year, collecting 95 tackles, 10.0 TFL, and seven sacks.
• Denzel Burke collected two interceptions while adding 42 tackles, 3.0 TFL, and two passes defended last year.

Grambling Tigers

• Myles Crawley threw for 1,598 yards and 11 touchdowns last season.
• Ketravion Hargrove averaged 42.1 rushing yards and collected five rushing touchdowns.
• Last season Tre Bradford rushed for 325 yards. He also scored five total touchdowns.
• Javon Robinson averaged 46.1 yards on 3.6 receptions per game and compiled one receiving touchdown in 2024.
• Nicholas Howard grabbed two touchdowns and had 273 receiving yards (27.3 ypg) in 2024.
• Marquis Harris worked his way to one receiving touchdown and 183 receiving yards (20.3 ypg) last season.
• Last year Jonathan Horton accumulated 4.5 sacks, four tackles.
• Blake Davis put together an excellent stat line last year, collecting eight tackles, 1.0 TFL, two sacks, and three interceptions.
• Brenden Barley collected three interceptions in addition to one sack a year ago.