The Iowa Hawkeyes (1-0) visit the No. 16 Iowa State Cyclones (2-0) at Jack Trice Stadium on Saturday, September 6, 2025.

The Hawkeyes are underdogs, but by less than a touchdown (+3.5), against the Cyclones (with an over/under of 43 points).

Read on for our preview for this this contest between the Cyclones and the Hawkeyes, and find all of our betting picks here, too!

Iowa State vs. Iowa betting lines

• Spread favorite: Cyclones (-3.5)
• Moneyline: Cyclones (-172), Hawkeyes (+144)
• Total: 43 points
• TV Channel: FOX (KNIN-Boise, ID)
• Live Stream: Fubo

Iowa State vs. Iowa betting info and stats

Iowa State has won two games against the spread so far this season (2-0-0). Iowa State has always covered the spread when the favorite by at least 3.5 points (a 1-0 ATS record). Iowa State won the only game it played as the moneyline favorite this season. Iowa, through one game with a set spread so far this season, has gone 0-1-0 against the spread. Iowa has not played as an underdog on the moneyline so far this season.

Iowa State vs. Iowa key players

Iowa State Cyclones

• Rocco Becht had a passing stat line last season of 3,505 yards with a 59.5% completion rate (272-for-457), 25 touchdowns, nine interceptions, and an average of 250.4 yards per game. His rushing stat line was 98 carries for 318 yards and eight TDs.
• Last year Carson Hansen took 151 carries for 752 yards (53.7 per game) and scored 13 touchdowns.
• Abu Sama III posted 587 rushing yards on 124 carries and two touchdowns last season.
• Jaylin Noel hauled in 81 catches for 1,194 yards (85.3 per game) while being targeted 128 times. He also scored eight touchdowns.
• Jayden Higgins tacked on 1,183 yards on 87 grabs with nine touchdowns. He was targeted 136 times, and averaged 91.0 receiving yards per game.
• Gabe Burkle grabbed 26 passes for 296 yards and one touchdown, putting up 22.8 yards per game last season.
• J.R. Singleton did his thing last season with an incredible stat line of 4.0 sacks, 3.0 TFL and 28 tackles.
• Last season Beau Freyler averaged 67 tackles, 2.0 TFL, and two interceptions.
• Jontez Williams intercepted four passes last year while also totaling 39 tackles, 2.0 TFL, and four passes defended.

Iowa Hawkeyes

• Cade McNamara averaged 127.1 yards passing per game and threw for six touchdowns last season.
• Kaleb Johnson racked up 21 rushing touchdowns on 128.1 yards per game last year. Johnson was also effective in the passing game, totaling 22 catches and two touchdowns over the course of the year.
• Kamari Moulton rushed for 473 yards and three touchdowns last season.
• Jacob Gill averaged 31.6 yards on 2.7 receptions per game and racked up two receiving touchdowns in 2024.
• Luke Lachey averaged 21.0 receiving yards on 3.6 targets per game in 2024.
• Last year Ethan Hurkett accumulated 6.5 sacks, 7.0 TFL and 48 tackles.
• Jay Higgins had an impressive defensive performance last season with 113 tackles, 2.0 TFL, one sack, and four interceptions.