The No. 20 Ole Miss Rebels (1-0) meet a conference opponent when they visit the Kentucky Wildcats (1-0) on Saturday, September 6, 2025 at Kroger Field in an SEC clash.

The Rebels are significant favorites (-9.5) in their game against the Wildcats, with the over/under at 50.5 points. (In terms of the moneyline, the Rebels are -339 and the Wildcats are +268.)

Keep reading for our betting preview for this this matchup between the Rebels and the Wildcats, and find all of our expert picks here, too!

Ole Miss vs. Kentucky betting lines

• Spread favorite: Rebels (-9.5)
• Moneyline: Rebels (-339), Wildcats (+268)
• Total: 50.5 points
• TV Channel: ABC (WLS – Chicago, IL)
• Live Stream: Fubo

Ole Miss vs. Kentucky betting info and stats

Ole Miss has won just one game against the spread this season (1-0-0). Ole Miss is undefeated ATS (1-0) when the favorite by at least 9.5 points. In one game as a moneyline favorite, Ole Miss won. Kentucky has yet to win a game against the spread so far this season (0-1-0). Kentucky has not been listed as the underdog on the moneyline yet this season.

Ole Miss vs. Kentucky key players

Ole Miss Rebels

• Last season Jaxson Dart had a monster stat line with 4,279 passing yards (329.2 per game), a 69.3% completion percentage (276-for-398), 29 touchdowns, and only six interceptions. He also added 496 rushing yards on 124 carries with three rushing TDs (averaging 38.2 yards per game).
• Last year, Henry Parrish Jr. rushed for 693 yards on 131 carries (77.0 yards per game) and scored 10 times.
• In the previous season, Cleveland Joseph Harris III grabbed 61 passes (on 79 targets) for 1,063 yards (132.9 per game). He also found the end zone seven times.
• Jordan Watkins also impressed receiving last year. He bagged 49 receptions for 906 yards and nine touchdowns. He was targeted 73 times.
• Cayden Lee reeled in 57 passes for 874 yards and two touchdowns, putting up 67.2 yards per game last year.
• Last season Suntarine Perkins stacked up 10.5 sacks, 13.0 TFL, 59 tackles, and one interception.
• Chris Paul Jr. went to work last year, collecting 86 tackles, 9.0 TFL, 3.5 sacks, and one interception.
• Trey Amos collected three interceptions while adding 48 tackles, 3.0 TFL, and three passes defended last year.

Kentucky Wildcats

• Brock Vandagriff threw for 1,593 yards and 10 touchdowns last season. He also chipped in on the ground, accumulating 131 yards.
• Jamarion Wilcox averaged 49.2 rushing yards and accumulated two rushing touchdowns.
• Demie Sumo ran for five touchdowns on 586 yards a year ago.
• Dane Key averaged 59.6 receiving yards and racked up two receiving touchdowns over the course of the 2024 season.
• Barion Brown hauled in three touchdowns and had 361 receiving yards (32.8 ypg) in 2024.
• Jay Maclin worked his way to four receiving touchdowns and 313 receiving yards (28.5 ypg) last season.
• Last year J.J. Weaver put pressure on opposing quarterbacks with 5.0 sacks, and added 5.0 TFL and 24 tackles.
• Jamon Dumas-Johnson was all over the field last season with 60 tackles, 4.0 TFL, 3.5 sacks, and one interception.
• Jordan Lovett collected two interceptions in addition to 52 tackles, 1.0 TFL, and two passes defended a year ago.