The Oklahoma State Cowboys (1-0) visit the No. 6 Oregon Ducks (1-0) at Autzen Stadium on Saturday, September 6, 2025.

The Ducks are expected to win by at least two touchdowns (currently -28) versus the Cowboys. The over/under for this matchup is 55.5 points.

Read on for our preview for this this contest between the Ducks and the Cowboys, and discover all of our predictions here, too!

Oregon vs. Oklahoma State betting lines

• Spread favorite: Ducks (-28)
• Moneyline: Ducks (-6667), Cowboys (+1810)
• Total: 55.5 points
• TV Channel: CBS (KBAK-Bakersfield, CA)
• Live Stream: Fubo

Oregon vs. Oklahoma State betting info and stats

Oregon has a single win against the spread this season (1-0-0). In one game played when favored by at least 28 points, Oregon covered the spread. In one game as a moneyline favorite, Oregon won. Oklahoma State, through one game with a set spread this season, has gone 0-1-0 against the spread. Oklahoma State has not been listed as an underdog on the moneyline so far this season.

Oregon vs. Oklahoma State key players

Oregon Ducks

• Last year Dillon Gabriel had 3,857 passing yards (275.5 per game), a 72.9% completion percentage, 30 touchdowns, and six interceptions. He also added 149 rushing yards on 75 carries with seven rushing TDs (averaging 10.6 rushing yards per game).
• Last year, Jordan James ran for 1,267 yards on 233 attempts (90.5 yards per game) and scored 15 times.
• Noah Whittington put up 540 rushing yards on 118 carries and six touchdowns last season.
• Tez Johnson collected 83 receptions for 898 yards and 10 touchdowns last year. He was targeted 103 times, and averaged 74.8 yards per game.
• Traeshon Holden tacked on 718 yards on 45 grabs with five touchdowns. He was targeted 54 times, and averaged 55.2 receiving yards per game.
• Evan Stewart reeled in 48 passes on 71 targets for 613 yards and five touchdowns, compiling 47.2 receiving yards per game.
• Matayo Uiagalelei did his thing last season with a huge stat line of 10.5 sacks, 9.0 TFL, 37 tackles, and one interception.
• Bryce Boettcher went to work last year, collecting 81 tackles, 6.0 TFL, two sacks, and one interception.
• Tysheem Johnson collected three interceptions while adding 65 tackles, 1.0 TFL, and three passes defended last year.

Oklahoma State Cowboys

• Alan Bowman completed 60% of his passes to throw for 2,442 yards and 17 touchdowns last season.
• Ollie Gordon II racked up 12 rushing touchdowns on 71.5 yards per game last season. Gordon was also productive in the passing game, accumulating 30 catches and two touchdowns over the course of the year.
• Trent Howland ran for one touchdown on 230 yards a year ago.
• De’Zhaun Stribling averaged 74.3 receiving yards and racked up six receiving touchdowns over the course of the 2024 season.
• Brennan Presley caught 89 passes last season on his way to 764 yards and seven receiving touchdowns.
• Rashod Owens caught 32 passes on his way to 515 receiving yards and four touchdowns a season ago.
• Last year Kendal Daniels racked up 5.5 sacks, 8.0 TFL and 55 tackles.
• Trey Rucker had an impressive defensive performance last season with 82 tackles, 1.0 TFL, and two interceptions.
• Korie Black collected three interceptions in addition to 29 tackles and three passes defended a year ago.