The Vanderbilt Commodores (0-0) take on an FCS opponent, the Charleston Southern Buccaneers (0-0), on Saturday, August 30, 2025 at FirstBank Stadium.

The Buccaneers are expected to lose by at least two TDs (currently +37.5) versus the Commodores (with an over/under of 48.5 points).

Keep reading for our betting primer for this this game between the Commodores and the Buccaneers, and find all of our predictions here, too!

Vanderbilt vs. Charleston Southern betting lines

• Spread favorite: Commodores (-37.5)
• Moneyline: Commodores (), Buccaneers ()
• Total: 48.5 points

Vanderbilt vs. Charleston Southern betting info and stats

• Vanderbilt was 9-4-0 against the spread last year.
• Vanderbilt had seven of its 13 games go over the point total last year.
• Charleston Southern had six wins in 11 games against the spread last year.
• Last season, three of Charleston Southern’s 11 games hit the over.

Vanderbilt vs. Charleston Southern key players

Vanderbilt Commodores

• Last season Diego Pavia had 2,293 passing yards (176.4 per game), a 59.4% completion percentage (177-for-298), 20 touchdowns, and only four interceptions. He also added 800 rushing yards on 193 carries with eight rushing TDs (averaging 61.5 yards per game).
• Sedrick Alexander ran for 586 yards on 164 carries (45.1 yards per game), with six rushing touchdowns last year. He also made his name known on the passing side with 23 receptions for 238 yards (18.3 per game) and one TD.
• In the previous year, Eli Stowers grabbed 49 passes (on 76 targets) for 638 yards (49.1 per game). He also found the end zone five times.
• Junior Sherrill produced last year, grabbing 29 passes for 411 yards and three touchdowns. He collected 31.6 receiving yards per game.
• Quincy Skinner Jr.’s stat line last season: 367 receiving yards, 29 catches, three touchdowns, on 51 targets.
• Nicholas Rinaldi’s hard work last season put up a stat line of 6.0 sacks, 6.0 TFL and 38 tackles.
• Bryan Longwell went to work last year, collecting 72 tackles, 5.0 TFL, 1.5 sacks, and one interception.
• Last season Martel Hight had a huge stat line of two interceptions, 30 tackles, 1.0 TFL, and two passes defended.

Charleston Southern Buccaneers

• Kaleb Jackson threw for 826 yards and five touchdowns last season. He also chipped in on the ground, tallying two touchdowns while racking up 111 yards.
• Autavius Ison averaged 79.0 rushing yards and tallied four rushing touchdowns.
• Tyson Greenwade rushed for 467 yards and three touchdowns last season.
• Chris Rhone averaged 48.8 receiving yards and grabbed four receiving touchdowns over the course of the 2024 season.
• Noah Jennings averaged 39.6 receiving yards on 4.2 targets per game in 2024, scoring three touchdowns.
• Jamil Bishop worked his way to one receiving touchdown and 167 receiving yards (20.9 ypg) last season.
• Darrius Bell proved to be a strong defender last year, recording 6.0 sacks, 1.0 TFL.
• Josh Hill put together a strong stat line last year, tallying 1.0 TFL and two sacks.
• A year ago Kason Hooks collected 1.0 TFL and two sacks as well as one interception.