The Kansas Jayhawks (2-0) visit the Missouri Tigers (1-0) at Memorial Stadium/Faurot Field on Saturday, September 6, 2025.

The Tigers are favored, but by less than a touchdown (-5.5), versus the Jayhawks. The over/under for this game is 49.5 points.

Below you can find our betting primer for this this matchup between the Tigers and the Jayhawks, and discover all of our predictions here, too!

Missouri vs. Kansas betting lines

• Spread favorite: Tigers (-5.5)
• Moneyline: Tigers (-211), Jayhawks (+174)
• Total: 49.5 points
• TV Channel: ESPN2
• Live Stream: Fubo

Missouri vs. Kansas betting info and stats

Missouri has been perfect against the spread (1-0-0) so far this season. In one game played when favored by at least 5.5 points, Missouri covered the spread. In one game as the moneyline favorite, Missouri won. Kansas has won just one game against the spread this season (1-1-0). Kansas has not been an underdog on the moneyline so far this season.

Missouri vs. Kansas key players

Missouri Tigers

• Brady Cook had a passing stat line last season of 2,525 yards with a 62.5% completion rate (200-for-320), 11 touchdowns, two interceptions, and an average of 210.4 yards per game. His rushing stat line was 87 carries for 223 yards and five TDs.
• Nate Noel churned out 818 rushing yards (74.4 per game) and three touchdowns last season.
• Marcus Carroll ran for 595 yards on 140 carries (45.8 yards per game), with 12 rushing touchdowns last year.
• In the previous season, Theo Wease Jr. grabbed 60 passes (on 100 targets) for 884 yards (68.0 per game). He also found the end zone four times.
• Luther Burden III produced last season, catching 60 passes for 666 yards and six touchdowns. He collected 55.5 receiving yards per game.
• Marquis Johnson hauled in 25 passes for 352 yards and one touchdown, averaging 32.0 yards per game last year.
• Last season Johnny Walker Jr. racked up 9.5 sacks, 10.0 TFL and 33 tackles.
• Corey Flagg Jr. was a wrecking ball on the field, collecting 71 tackles, 4.0 TFL, one sack, and one interception last year.
• Last season Toriano Pride Jr. had a huge stat line of two interceptions, 15 tackles and two passes defended.

Kansas Jayhawks

• Jalon Daniels tossed 14 touchdowns and 12 interceptions while accumulating 2,454 yards by the end of last season (204.5 ypg). He also scored six touchdowns on 37.3 rushing yards per game.
• Devin Marques Neal averaged 105.5 rushing yards and accumulated 16 rushing touchdowns. Neal complemented his rushing performance with two receptions per game to average 21.2 receiving yards.
• Luke Grimm averaged 57.5 receiving yards and collected six receiving touchdowns over the course of the 2024 season.
• Quentin Skinner caught 25 passes last season on his way to 557 yards and four receiving touchdowns.
• Lawrence Arnold caught 26 passes on his way to 360 receiving yards and one touchdown a season ago.
• Last year Jereme Robinson put pressure on opposing quarterbacks with 5.5 sacks, and added 7.0 TFL and 19 tackles.
• JB Brown put together an excellent stat line last year, tallying 64 tackles, 8.0 TFL, and five sacks.
• Mello Dotson came up with five interceptions in addition to 44 tackles, 1.0 TFL, and seven passes defended a year ago.