The Pittsburgh Panthers (0-0) face an FCS opponent, the Duquesne Dukes (0-0), on Saturday, August 30, 2025 at Acrisure Stadium.

The Dukes are expected to lose by at least two touchdowns (currently +39.5) versus the Panthers (with an over/under of 57.5 points).

Read on for our betting preview for this this game between the Panthers and the Dukes, and discover all of our expert picks here, too!

Pittsburgh vs. Duquesne betting lines

• Spread favorite: Panthers (-39.5)
• Moneyline: Panthers (-100000), Dukes (+5000)
• Total: 57.5 points
• TV Channel: ACC Network
• Live Stream: Fubo

Pittsburgh vs. Duquesne betting info and stats

• Against the spread, Pittsburgh went 7-6-0 last year.
• Out of 13 Pittsburgh games last season, six hit the over.
• Against the spread, Duquesne was 5-5-0 last season.
• Last year, five of Duquesne’s 10 games went over the point total.

Pittsburgh vs. Duquesne key players

Pittsburgh Panthers

• Eli Holstein put together an impressive passing stat line last year with 2,228 yards (222.8 yards per game), going 180-for-290 (62.1% completion percentage), 17 touchdowns and seven interceptions. He was a factor in the running game as well, with 328 rushing yards on 81 carries, three rushing TDs, and averaging 32.8 yards per game.
• Desmond Reid took 183 carries for 962 yards (80.2 per game) and scored five touchdowns last season. When it comes to receiving, he caught 52 passes for 579 yards (52.6 per game) and four TDs.
• Konata Mumpfield hauled in 52 catches for 813 yards (67.8 per game) while being targeted 84 times. He also scored five touchdowns.
• Kenny Johnson reeled in 46 passes for 537 yards and three touchdowns, putting up 41.3 yards per game last year.
• Kyle Louis’ hard work last season put together a stat line of 7.0 sacks, 13.0 TFL, 83 tackles, and four interceptions.
• Donovan McMillon went to work last year, collecting 89 tackles, 1.0 TFL, and one interception.
• Louis intercepted four passes last year while also totaling 83 tackles, 13.0 TFL, seven sacks, and four passes defended.

Duquesne Dukes

• Darius Perrantes completed 57.8% of his passes to throw for 2,337 yards and 29 touchdowns last season.
• JaMario Clements compiled 986 rushing yards and six touchdowns on the ground during last year’s campaign.
• Taj Butts ran for 268 yards a year ago.
• Joey Isabella averaged 68.2 yards on 3.8 receptions per game and compiled 11 receiving touchdowns in 2024.
• John Erby averaged 60.7 receiving yards on 4.5 targets per game in 2024, scoring eight touchdowns.
• Tedy Afful hauled in 46 passes on his way to 600 receiving yards and six touchdowns a season ago.
• Last year Jack Dunkley racked up 9.5 sacks, 1.0 TFL and five tackles.
• Antonio Epps had an impactful defensive performance last season with 12 tackles, 1.0 TFL, and one interception.
• A year ago Ty Howard tallied seven tackles and four sacks as well as three interceptions.